Tag | Content |
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CPLM ID | CPLM-017924 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tetratricopeptide repeat protein 8 |
Protein Synonyms/Alias | TPR repeat protein 8; Bardet-Biedl syndrome 8 protein |
Gene Name | TTC8 |
Gene Synonyms/Alias | BBS8 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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184 | LSRLNLTKYSQKPKL | ubiquitination | [1] | 223 | STEHSQYKDWWWKVQ | ubiquitination | [1] | 233 | WWKVQIGKCYYRLGM | ubiquitination | [1] | 253 | KQFKSALKQQEMVDT | ubiquitination | [1] | 477 | NFATISDKIGDLQRS | ubiquitination | [1] | 490 | RSYVAAQKSEAAFPD | ubiquitination | [1] | 506 | VDTQHLIKQLRQHFA | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. |
Sequence Annotation | REPEAT 14 47 TPR 1. REPEAT 251 284 TPR 2. REPEAT 285 317 TPR 3. REPEAT 318 351 TPR 4. REPEAT 352 385 TPR 5. REPEAT 386 419 TPR 6. REPEAT 423 456 TPR 7. REPEAT 457 490 TPR 8. |
Keyword | Alternative splicing; Bardet-Biedl syndrome; Cell membrane; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Membrane; Mental retardation; Obesity; Reference proteome; Repeat; Retinitis pigmentosa; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 541 AA |
Protein Sequence | MSSEMEPLLL AWSYFRRRKF QLCADLCTQM LEKSPYDQEP DPELPVHQAA WILKARALTE 60 MVYIDEIDVD QEGIAEMMLD ENAIAQVPRP GTSLKLPGTN QTGGPSQAVR PITQAGRPIT 120 GFLRPSTQSG RPGTMEQAIR TPRTAYTARP ITSSSGRFVR LGTASMLTSP DGPFINLSRL 180 NLTKYSQKPK LAKALFEYIF HHENDVKTAL DLAALSTEHS QYKDWWWKVQ IGKCYYRLGM 240 YREAEKQFKS ALKQQEMVDT FLYLAKVYVS LDQPVTALNL FKQGLDKFPG EVTLLCGIAR 300 IYEEMNNMSS AAEYYKEVLK QDNTHVEAIA CIGSNHFYSD QPEIALRFYR RLLQMGIYNG 360 QLFNNLGLCC FYAQQYDMTL TSFERALSLA ENEEEAADVW YNLGHVAVGI GDTNLAHQCF 420 RLALVNNNNH AEAYNNLAVL EMRKGHVEQA RALLQTASSL APHMYEPHFN FATISDKIGD 480 LQRSYVAAQK SEAAFPDHVD TQHLIKQLRQ HFAML 515 |
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