CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011859
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleolar protein 56 
Protein Synonyms/Alias
 Ribosome biosynthesis protein SIK1; Suppressor of I kappa b protein 1 
Gene Name
 NOP56 
Gene Synonyms/Alias
 SIK1; YLR197W; L8167.9 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
327GSLTNLSKQAASTVQubiquitination[1]
340VQILGAEKALFRALKacetylation[2]
340VQILGAEKALFRALKubiquitination[1]
354KTKGNTPKYGLIYHSacetylation[2]
366YHSGFISKASAKNKGubiquitination[1]
382ISRYLANKCSMASRIubiquitination[1]
405NVFGSVLKKQVEQRLacetylation[2]
419LEFYNTGKPTLKNELacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Required for 60S ribosomal subunit synthesis. 
Sequence Annotation
 DOMAIN 299 417 Nop.
 MOD_RES 321 321 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 504 AA 
Protein Sequence
MAPIEYLLFE EPTGYAVFKV KLQQDDIGSR LKEVQEQIND FGAFTKLIEL VSFAPFKGAA 60
EALENANDIS EGLVSESLKA ILDLNLPKAS SKKKNITLAI SDKNLGPSIK EEFPYVDCIS 120
NELAQDLIRG VRLHGEKLFK GLQSGDLERA QLGLGHAYSR AKVKFSVQKN DNHIIQAIAL 180
LDQLDKDINT FAMRVKEWYG WHFPELAKLV PDNYTFAKLV LFIKDKASLN DDSLHDLAAL 240
LNEDSGIAQR VIDNARISMG QDISETDMEN VCVFAQRVAS LADYRRQLYD YLCEKMHTVA 300
PNLSELIGEV IGARLISHAG SLTNLSKQAA STVQILGAEK ALFRALKTKG NTPKYGLIYH 360
SGFISKASAK NKGRISRYLA NKCSMASRID NYSEEPSNVF GSVLKKQVEQ RLEFYNTGKP 420
TLKNELAIQE AMELYNKDKP AAEVEETKEK ESSKKRKLED DDEEKKEKKE KKSKKEKKEK 480
KEKKDKKEKK DKKEKKDKKK KSKD 504 
Gene Ontology
 GO:0030686; C:90S preribosome; IDA:SGD.
 GO:0031428; C:box C/D snoRNP complex; IDA:SGD.
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0000154; P:rRNA modification; TAS:SGD. 
Interpro
 IPR012974; NOP5_N.
 IPR002687; Nop_dom.
 IPR012976; NOSIC. 
Pfam
 PF01798; Nop
 PF08156; NOP5NT
 PF08060; NOSIC 
SMART
 SM00931; NOSIC 
PROSITE
 PS51358; NOP 
PRINTS