CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033410
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein-tyrosine kinase 2-beta 
Protein Synonyms/Alias
  
Gene Name
 PTK2B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
188LELRRFFKDMPHNALubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 213 AA 
Protein Sequence
MSGVSEPLSR VKLGTLRRPE GPAEPMVVVP VDVEKEDVRI LKVCFYSNSF NPGKNFKLVK 60
CTVQTEIREI ITSILLSGRI GPNIRLAECY GLRLKHMKSD EIHWLHPQMT VGEVQDKYEC 120
LHVEAEWRYD LQIRYLPEDF MESLKEDRTT LLYFYQQLRN DYMQRYASKV SEGMALQLGC 180
LELRRFFKDM PHNALDKKSN FELLEKEVGL DLF 213 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:Compara.
 GO:0042976; P:activation of Janus kinase activity; IEA:Compara.
 GO:0032863; P:activation of Rac GTPase activity; IEA:Compara.
 GO:0043534; P:blood vessel endothelial cell migration; IEA:Compara.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0070098; P:chemokine-mediated signaling pathway; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Compara.
 GO:0048041; P:focal adhesion assembly; IEA:Compara.
 GO:0014009; P:glial cell proliferation; IEA:Compara.
 GO:0000165; P:MAPK cascade; IEA:Compara.
 GO:0002315; P:marginal zone B cell differentiation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0030502; P:negative regulation of bone mineralization; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0001556; P:oocyte maturation; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:2000538; P:positive regulation of B cell chemotaxis; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010595; P:positive regulation of endothelial cell migration; IEA:Compara.
 GO:0043507; P:positive regulation of JUN kinase activity; IEA:Compara.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Compara.
 GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Compara.
 GO:0045727; P:positive regulation of translation; IEA:Compara.
 GO:2000249; P:regulation of actin cytoskeleton reorganization; IEA:Compara.
 GO:0050848; P:regulation of calcium-mediated signaling; IEA:Compara.
 GO:0008360; P:regulation of cell shape; IEA:Compara.
 GO:0030826; P:regulation of cGMP biosynthetic process; IEA:Compara.
 GO:0010752; P:regulation of cGMP-mediated signaling; IEA:Compara.
 GO:2000114; P:regulation of establishment of cell polarity; IEA:Compara.
 GO:0032960; P:regulation of inositol trisphosphate biosynthetic process; IEA:Compara.
 GO:0010758; P:regulation of macrophage chemotaxis; IEA:Compara.
 GO:0045428; P:regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0009725; P:response to hormone stimulus; IEA:Compara.
 GO:0042542; P:response to hydrogen peroxide; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0010226; P:response to lithium ion; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0006970; P:response to osmotic stress; IEA:Compara.
 GO:0002040; P:sprouting angiogenesis; IEA:Compara.
 GO:0043149; P:stress fiber assembly; IEA:Compara.
 GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Compara. 
Interpro
 IPR019749; Band_41_domain.
 IPR019748; FERM_central.
 IPR000299; FERM_domain. 
Pfam
 PF00373; FERM_M 
SMART
 SM00295; B41 
PROSITE
 PS50057; FERM_3 
PRINTS