CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear receptor coactivator 6 
Protein Synonyms/Alias
  
Gene Name
 Ncoa6 
Gene Synonyms/Alias
 mCG_21081 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1824SSSKGKGKVDKIGQIacetylation[1, 2]
1827KGKGKVDKIGQILLTacetylation[1, 2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2069 AA 
Protein Sequence
MVLDDLPNFE DIYTSLCSST MGDSEVEFDS GLEDDDTKSD SILEDSTIFV AFKGNIDDKD 60
FKWKLDAILK NVPNLLHMES SKLKVQKVEP WNSVRVTFNI PREAAERLRI LAQSNNQQLR 120
DLGILSVQIE GEGAINLALG QNRSQDVRMN GPVASGNSVR MEAGFPMASG PGLIRMTSPA 180
AVMTPQGGNM SSSMMAPGPN PELQPRTPRP ASQSDAMDPL LSGLHIQQQS HPSGSLPPAH 240
HSMQPVPVNR QMNPANFPQL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQLQTRPLQQ 300
HQQQPQGIRP QFTAPTQVPV PPGWNQLPSG ALQPPPAQGS LGTMTTNQGW KKAPLPSPMQ 360
AQLQARPSLA TVQTPSHPPP PYPFGSQQAS QAHTNFPQMS NPGQFTAPQM KGLQGGPSRV 420
PTPLQQPHLT NKSPASSPSS FQQGSPASSP TVNQTQQQMG PRPPQNNPLS QGFQQPVSSP 480
GRNPMVQQGN VPPNFMVMQQ QPPNQGPQSL HPGLGGMPKR LPPGFSAGQA NPNFMQGQVP 540
STTAATPGNS GALQLQANQN VQHAGGQGAG PPQNQMQVSH GPPNMMQPSL MGIHGNINNQ 600
QAGSSGVPQV TLGNMQGQPQ QGPPSQLMGM HQQIVPSQGQ MAQQQGTLNP QNPMILSRAQ 660
LMPQGQMMVN AQNQNLGPSP QRMTPPKQML PQQGPQMMAP HNQMMGPQGQ VLLQQNPMIE 720
QIMTNQMQGN KAQFNSQNQS NVMPGPAQIM RGPTPNMQGN MVQFTGQMSG QMLPQQGPVN 780
NSPSQVMGIQ GQVLRPPGPS PHMAQQHNDP VTTANNDVNL SQMMPDVSMQ QASMVPPHVQ 840
SMQGNSASGS HFSGHGVSFN APFGGAPNGS QMSCGQNPGF PVNKDVTLTS PLLVNLLQSD 900
ISAGHFGVNN KQNNTNANKP KKKKPPRKKK NCHQDLNTPD NRPTGLEEVD QQSLPGEQGI 960
NLDTTGPKLP DFSNRPPGYP TQPVEQRPLP QMPPQLMQHV APPPQPPQQQ PQPQLPQQQQ 1020
PPPPSQPQSQ QQQQQQQMMM MLMMQQDPKS IRLPVSQNVH PPRGPLNPDS QRMPVQQSGN 1080
VPVMVGLQGP ASVPPSPDKQ RMPMSVNTPM GSNSRKMVYQ ENPQNSSSSP LGEMSSLPEA 1140
SGSEVPSVAG GPNNMPSHLV VSQNQLMMTG PKPGPSPLSA TQGATPQQPP VNSLPSSHGH 1200
HFPNVAAPTQ TSRPKTPNRA SPRPYYPQTP NNRPPSTEPS EISLSPERLN ASIAGLFPPQ 1260
INIPLPPRPN LNRGFDQQGL NPTTLKAIGQ APSNLTITNP PNFAAPQAHK LDSVVVNSGK 1320
QSNPGTTKRA SPSNSRRSSP GSSRKTTPSP GRQNSKAPKL TLASQTSTTM LQNMELPRNV 1380
LVGPTPLANP PLPGSFPNNT GLNPQNPTVP VPAMGTVLED NKESVNIPQD SDCQNAQGRK 1440
EQVNTELKVV PTQEAKMAVP EDQSKKDGQP LDPNKLPSVE ENKNLMSPAM REAPTSLSQL 1500
LDNSGAPNVT IKPPGLTDLE VTPPVVSGED LRKASVIPTL QDPPSKEPST SLSSPHSSEP 1560
CSTLARSELS EVSSNTAPSI PPVMSRPVSS SSISTPLPPN QITVFVTSNP ITTSSNTSAA 1620
LPTHLQSALM STVVTMPNVG NKVMVSEGQS AAQSNARPQF ITPVFINSSS IIQVMKGSQP 1680
STIPATPLTT NSGLMPPSVA VVGPLHIPQN IKFSSAPVTP NVPSSSPAPN IQTGRPLVLS 1740
SRATPVQLPS PPCTSSPVVA PNPSVQQVKE LNPDEASPQT NTSADQSTLP PSQPTTVVSP 1800
LLTNSPGSSA NRRSPVSSSK GKGKVDKIGQ ILLTKACKKV TGSLEKGEEQ YGADGETEGP 1860
GLEITTPGLM GTEQCSTELD SKTPTPSAPT LLKMTSSPMG PSSTSTGPIL PGGALPTSVR 1920
SIVTTLVPSE LISTAPTTKG NHGGVTSEPL AGGLVEEKVG SHPELLPSIA PSQNLAPKET 1980
PATALQGSVA RPELEANAAI ASGQSCEPKE IVEKSKTLTS RRNSRTEEPT MASESVENGH 2040
RKRSSRPASA SSSTKDITGA VQSKRRKSK 2069 
Gene Ontology
 GO:0035097; C:histone methyltransferase complex; ISO:MGI.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0007420; P:brain development; IMP:MGI.
 GO:0006352; P:DNA-dependent transcription, initiation; IEA:Compara.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI.
 GO:0030099; P:myeloid cell differentiation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0006974; P:response to DNA damage stimulus; ISO:MGI. 
Interpro
 IPR026638; NCOA6. 
Pfam
  
SMART
  
PROSITE
  
PRINTS