CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024083
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Copine-6 
Protein Synonyms/Alias
 Copine VI; Neuronal-copine; N-copine 
Gene Name
 Cpne6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
171DNKDLFSKSDPFMEIubiquitination[1]
180DPFMEIYKTNGDQSDubiquitination[1]
197VWRTEVVKNNLNPSWubiquitination[1]
355CQDYDSDKRFPAFGFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity). May have a role in synaptic plasticity. 
Sequence Annotation
 DOMAIN 24 111 C2 1.
 DOMAIN 138 243 C2 2.
 DOMAIN 306 526 VWFA.
 MOD_RES 65 65 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MSDPEMGWVP EPPAMTLGAS RVELRVSCHG LLDRDTLTKP HPCVLLKLYS DEQWVEVERT 60
EVLRSCSSPV FSRVLAIEYF FEEKQPLQFH VFDAEDGATS PSSDTFLGST ECTLGQIVSQ 120
TKVTKPLLLK NGKTAGKSTI TIVAEEVSGT NDYVQLTFRA HKLDNKDLFS KSDPFMEIYK 180
TNGDQSDQLV WRTEVVKNNL NPSWEPFRLS LHSLCSCDIH RPLKFLVYDY DSSGKHDFIG 240
EFTSTFQEMQ EGTANPGQEM QWDCINPKYR DKKKNYKSSG TVVLAQCTVE KVHTFLDYIM 300
GGCQISFTVA IDFTASNGDP RSSQSLHCLS PRQPNHYLQA LRTVGGICQD YDSDKRFPAF 360
GFGARIPPNF EVSHDFAINF DPENPECEEI SGVIASYRRC LPQIQLYGPT NVAPIINRVA 420
EPAQREQSTG QATKYSVLLV LTDGVVSDMA ETRTAIVRAS RLPMSIIIVG VGNADFSDMR 480
LLDGDDGPLR CPKGVPAARD IVQFVPFRDF KDAAPSALAK CVLAEVPRQV VEYYASQGIS 540
PGAPRPSTPA MTPSPSP 557 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0030425; C:dendrite; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0001786; F:phosphatidylserine binding; IDA:MGI. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR010734; Copine.
 IPR002035; VWF_A. 
Pfam
 PF00168; C2
 PF07002; Copine 
SMART
 SM00239; C2
 SM00327; VWA 
PROSITE
 PS50004; C2
 PS50234; VWFA 
PRINTS