CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008808
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional regulator CRZ1 
Protein Synonyms/Alias
  
Gene Name
 CRZ1 
Gene Synonyms/Alias
 HAL8; TCN1; YNL027W; N2760 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
71DSANSSEKISKNLSSubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates PMC1, PMR1, PMR2A and FKS2. 
Sequence Annotation
 ZN_FING 569 591 C2H2-type 1.
 ZN_FING 597 619 C2H2-type 2.
 MOD_RES 170 170 Phosphothreonine.
 MOD_RES 175 175 Phosphoserine.
 MOD_RES 245 245 Phosphoserine.
 MOD_RES 385 385 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 678 AA 
Protein Sequence
MSFSNGNMAS YMTSSNGEEQ SINNKNDIDD NSAYRRNNFR NSSNSGSHTF QLSDLDLDVD 60
MRMDSANSSE KISKNLSSGI PDSFDSNVNS LLSPSSGSYS ADLNYQSLYK PDLPQQQLQQ 120
QQLQQQQQQQ QQQQQQQQKQ TPTLKVEQSD TFQWDDILTP ADNQHRPSLT NQFLSPRSNY 180
DGTTRSSGID SNYSDTESNY HTPYLYPQDL VSSPAMSHLT ANNDDFDDLL SVASMNSNYL 240
LPVNSHGYKH ISNLDELDDL LSLTYSDNNL LSASNNSDFN NSNNGIINTA DTQNSTIAIN 300
KSKVGTNQKM LLTIPTSSTP SPSTHAAPVT PIISIQEFNE GHFPVKNEDD GTLQLKVRDN 360
ESYSATNNNN LLRPDDNDYN NEALSDIDRS FEDIINGRKL KLKKSRRRSS QTSNNSFTSR 420
RSSRSRSISP DEKAKSISAN REKLLEMADL LPSSENDNNR ERYDNDSKTS YNTINSSNFN 480
EDNNNNNLLT SKPKIESGIV NIKNELDDTS KDLGILLDID SLGQFEQKVG FKNDDNHENN 540
DNGTFSVKKN DNLEKLDSVT NNRKNPANFA CDVCGKKFTR PYNLKSHLRT HTNERPFICS 600
ICGKAFARQH DRKRHEDLHT GKKRYVCGGK LKDGKPWGCG KKFARSDALG RHFKTESGRR 660
CITPLYEEAR QEKSGQES 678 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IDA:SGD.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006038; P:cell wall chitin biosynthetic process; IGI:SGD.
 GO:0071483; P:cellular response to blue light; IDA:SGD.
 GO:2001040; P:positive regulation of cellular response to drug; IMP:SGD.
 GO:0061423; P:positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter; IDA:SGD.
 GO:1900622; P:positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling; IMP:SGD.
 GO:0007329; P:positive regulation of transcription from RNA polymerase II promoter by pheromones; IMP:SGD.
 GO:0061422; P:positive regulation of transcription from RNA polymerase II promoter in response to alkalinity; IMP:SGD.
 GO:0061400; P:positive regulation of transcription from RNA polymerase II promoter in response to calcium ion; IMP:SGD.
 GO:0061404; P:positive regulation of transcription from RNA polymerase II promoter in response to increased salt; IMP:SGD.
 GO:0097301; P:regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter; IMP:SGD. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS