CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030057
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenosine A2B receptor 
Protein Synonyms/Alias
 Adenosine receptor A2b 
Gene Name
 Adora2b 
Gene Synonyms/Alias
 rCG_33660 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
265LFHPALAKDKPKWVMacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; G-protein coupled receptor; Membrane; Receptor; Reference proteome; Transducer; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 332 AA 
Protein Sequence
MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA TADVAVGLFA 60
IPFAITISLG FCTDFHSCLF LACFVLVLTQ SSIFSLLAVA VDRYLAIRVP LRYKGLVTGT 120
RARGIIAVLW VLAFGIGLTP FLGWNSKDRA TSNCTEPGDG ITNKSCCPVK CLFENVVPMS 180
YMVYFNFFGC VLPPLLIMMV IYIKIFMVAC KQLQHMELME HSRTTLQREI HAAKSLAMIV 240
GIFALCWLPV HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPVVY AYRNRDFRYS 300
FHRIISRYVL CQTDTKGGSG QAGGQSTFSL SL 332 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0001609; F:G-protein coupled adenosine receptor activity; IEA:InterPro.
 GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0031668; P:cellular response to extracellular stimulus; IEA:Compara.
 GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Compara.
 GO:0030828; P:positive regulation of cGMP biosynthetic process; IEA:Compara.
 GO:0032722; P:positive regulation of chemokine production; IEA:Compara.
 GO:0002882; P:positive regulation of chronic inflammatory response to non-antigenic stimulus; IEA:Compara.
 GO:0031284; P:positive regulation of guanylate cyclase activity; IEA:Compara.
 GO:0032755; P:positive regulation of interleukin-6 production; IEA:Compara.
 GO:0043306; P:positive regulation of mast cell degranulation; IEA:Compara.
 GO:0010575; P:positive regulation vascular endothelial growth factor production; IEA:Compara.
 GO:0060087; P:relaxation of vascular smooth muscle; IEA:Compara. 
Interpro
 IPR001435; Adeno_A2B_rcpt.
 IPR001634; Adenosn_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00554; ADENOSINA2BR.
 PR00424; ADENOSINER.
 PR00237; GPCRRHODOPSN.