| Tag | Content |
|---|
| CPLM ID | CPLM-027465 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | M17 leucyl aminopeptidase |
Protein Synonyms/Alias | |
Gene Name | LAP |
Gene Synonyms/Alias | PF14_0439 |
Created Date | July 27, 2013 |
Organism | Plasmodium falciparum (isolate 3D7) |
NCBI Taxa ID | 36329 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 540 | YRATLNSKYADINNI | acetylation | [1] | | 552 | NNISSSVKASSIVAS | acetylation | [1] |
|
Reference | [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development. Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L. Mol Microbiol. 2013 Aug;89(4):660-75. [ PMID: 23796209] |
Functional Description | |
Sequence Annotation | REGION 102 104 Sulfate 1 binding.
REGION 390 392 Sulfate 3 binding.
REGION 435 436 Sulfate 5 binding.
REGION 505 506 Sulfate 7 binding.
REGION 531 532 Sulfate 8 binding.
REGION 569 570 Sulfate 7 binding.
METAL 374 374 Zinc 1.
METAL 379 379 Magnesium.
METAL 379 379 Zinc 1.
METAL 379 379 Zinc 2.
METAL 399 399 Zinc 1.
METAL 459 459 Magnesium.
METAL 459 459 Zinc 2.
METAL 461 461 Magnesium.
METAL 461 461 Zinc 1.
METAL 461 461 Zinc 2.
BINDING 126 126 Sulfate 2; via amide nitrogen.
BINDING 220 220 Sulfate 2.
BINDING 392 392 Sulfate 4; via amide nitrogen.
BINDING 499 499 Sulfate 6.
BINDING 545 545 Sulfate 9.
BINDING 549 549 Sulfate 9.
BINDING 586 586 Sulfate 10. |
Keyword | 3D-structure; Aminopeptidase; Complete proteome; Hydrolase; Magnesium; Metal-binding; Protease; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 605 AA |
Protein Sequence | MYFSSLCKFL PISEKEKIYL NIVKKRFCKS NIYYNNNNNN IINYNKRGLK FYPFCNNLKK 60
NINFVNINNK KGINFHSINK ERKMASEVPQ VVSLDPTSIP IEYNTPIHDI KVQVYDIKGG 120
CNVEEGLTIF LVNNPGKENG PVKISSKVND KNVSEFLKDE NMEKFNVKLG TSKHFYMFND 180
NKNSVAVGYV GCGSVADLSE ADMKRVVLSL VTMLHDNKLS KLTVVFEINV DKNLFRFFLE 240
TLFYEYMTDE RFKSTDKNVN MEYIKHLGVY INNADTYKEE VEKARVYYFG TYYASQLIAA 300
PSNYCNPVSL SNAAVELAQK LNLEYKILGV KELEELKMGA YLSVGKGSMY PNKFIHLTYK 360
SKGDVKKKIA LVGKGITFDS GGYNLKAAPG SMIDLMKFDM SGCAAVLGCA YCVGTLKPEN 420
VEIHFLSAVC ENMVSKNSYR PGDIITASNG KTIEVGNTDA EGRLTLADAL VYAEKLGVDY 480
IVDIATLTGA MLYSLGTSYA GVFGNNEELI NKILNSSKTS NEPVWWLPII NEYRATLNSK 540
YADINNISSS VKASSIVASL FLKEFVQNTA WAHIDIAGVS WNFKARKPKG FGVRLLTEFV 600
LNDAL 605 |
Gene Ontology | GO:0020011; C:apicoplast; ISS:GeneDB_Pfalciparum. GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW. GO:0030145; F:manganese ion binding; IEA:InterPro. GO:0008235; F:metalloexopeptidase activity; IEA:InterPro. GO:0006508; P:proteolysis; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |