UniProt Accession

 PPCS_YEAST; P40506; D6VVK3 

Genbank Protein ID

 Z46728; BK006942 

Genbank Nucleotide ID

 CAA86711.1; DAA08469.2 

Protein Name

 Phosphopantothenate--cysteine ligase CAB2 

Protein Synonyms/Alias

 Coenzyme A biosynthesis protein 2; Phosphopantothenoylcysteine synthetase; PPC synthetase 

Gene Name

 CAB2 

Gene Synonyms/Alias

 YIL083C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
234	IQSGDNGKMGANNDT	ubiquitination	[1]
262	VNLDPVPKFLRRLVE	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. 

Sequence Annotation

  

Keyword

 Coenzyme A biosynthesis; Complete proteome; Cytoplasm; Ligase; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004632; F:phosphopantothenate--cysteine ligase activity; ISS:SGD.
 GO:0015937; P:coenzyme A biosynthetic process; IGI:SGD. 

Interpro

 IPR007085; DNA/pantothenate-metab_flavo_C. 

Pfam

 PF04127; DFP 

SMART

  

PROSITE

  

PRINTS