| Tag | Content |
|---|
| CPLM ID | CPLM-013045 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 746 |
Protein Synonyms/Alias | |
Gene Name | Znf746 |
Gene Synonyms/Alias | Zfp746 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 438 | RTKGFGHKPGLKKHP | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death (By similarity). |
Sequence Annotation | DOMAIN 96 167 KRAB.
ZN_FING 454 479 C2H2-type 1; degenerate.
ZN_FING 517 539 C2H2-type 2.
ZN_FING 545 567 C2H2-type 3.
ZN_FING 573 595 C2H2-type 4. |
Keyword | Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 652 AA |
Protein Sequence | MAEAAAAPIS PWTMAATIQA MERKIESQAA RLLSLEGRTG MAEKKLADCE KTAVEFSNQL 60
EGKWAVLGTL LQEYGLLQRR LENVENLLRN RNFWILRLPP GSKGEVPKEW GKLEDWQKEL 120
YKHVMRGNYE TLVSLDYAIS KPEVLSQIEQ GKEPCTWRRT GPKVPEVPVD PSPGSGAPVP 180
APDLLMQIKQ EGELQLQEQQ ALGVEAWAAG QPDIGEEPWG LSQLDSGAGD ISTDATSGVH 240
SNFSTTIPPT SWQADLPPHH PSSACSDGTL KLNTAASTEA DVKIVIKTEV QEEEVVATPV 300
HPTDLEAHGT LFAPGQATRF FPSPVQEGAW ESQGSSFPSQ DPVLGLREPT RPERDIGELS 360
PAIAQEEAPA GDWLFGGVRW GWNFRCKPPV GLNPRTVPEG LPFSSPDNGE AILDPSQAPR 420
PFNDPCKYPG RTKGFGHKPG LKKHPAAPPG GRPFTCATCG KSFQLQVSLS AHQRSCGLSD 480
GAATGAASTT TGGGGGGSGG GGGSSGGGSS ARDSSALRCG ECGRCFTRPA HLIRHRMLHT 540
GERPFPCTEC EKRFTERSKL IDHYRTHTGV RPFTCTVCGK SFIRKDHLRK HQRNHPAVAK 600
APAHGQPLPP LPAPPDPFKS PAAKGPMAST DLVTDWTCGL SVLGPSDGGG DL 652 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0070997; P:neuron death; ISS:UniProtKB. GO:0010941; P:regulation of cell death; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |