UniProt Accession

 COFI_YEAST; Q03048; D6VXV8; Q05307; Q2XN65 

Genbank Protein ID

 Z14971; S52662; D13230; Z47973; Z73155; BK006945 

Genbank Nucleotide ID

 CAA78694.1; AAA13256.1; BAA02514.1; CAA88007.1; CAA97502.1; DAA09274.1 

Protein Name

 Cofilin 

Protein Synonyms/Alias

 Actin-depolymerizing factor 1 

Gene Name

 COF1 

Gene Synonyms/Alias

 YLL050C; L0596 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
20	LTAFNDLKLGKKYKF	acetylation	[1]
105	KMVYASSKDALRRAL	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton. In effect, yeast cofilin increases the rate of actin polymerization by making new ends available for actin subunit addition. Such a protein complex is important for the polarized growth of yeast cells. 

Sequence Annotation

 DOMAIN 5 137 ADF-H.
 MOD_RES 4 4 Phosphoserine.  

Keyword

 3D-structure; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 143 AA 

Protein Sequence

Gene Ontology

 GO:0030479; C:actin cortical patch; IDA:SGD.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0051015; F:actin filament binding; IDA:SGD.
 GO:0030042; P:actin filament depolymerization; IDA:SGD.
 GO:0051014; P:actin filament severing; IDA:SGD.
 GO:0006897; P:endocytosis; IMP:SGD.
 GO:0043001; P:Golgi to plasma membrane protein transport; IMP:SGD. 

Interpro

 IPR002108; Actin-bd_cofilin/tropomyosin.
 IPR017904; ADF/Cofilin/Destrin. 

Pfam

 PF00241; Cofilin_ADF 

SMART

 SM00102; ADF 

PROSITE

 PS51263; ADF_H 

PRINTS