CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004653
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Early growth response protein 1 
Protein Synonyms/Alias
 EGR-1; AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24 
Gene Name
 EGR1 
Gene Synonyms/Alias
 KROX24; ZNF225 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
317SYQSQLIKPSRMRKYacetylation[1]
422TKIHLRQKDKKADKSacetylation[2]
424IHLRQKDKKADKSVVacetylation[2]
425HLRQKDKKADKSVVAacetylation[2]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses.
 Yu J, de Belle I, Liang H, Adamson ED.
 Mol Cell. 2004 Jul 2;15(1):83-94. [PMID: 15225550] 
Functional Description
 Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. 
Sequence Annotation
 ZN_FING 338 362 C2H2-type 1.
 ZN_FING 368 390 C2H2-type 2.
 ZN_FING 396 418 C2H2-type 3.  
Keyword
 Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 543 AA 
Protein Sequence
MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG AAGAPEGSGS 60
NSSSSSSGGG GGGGGGSNSS SSSSTFNPQA DTGEQPYEHL TAESFPDISL NNEKVLVETS 120
YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW PEPLFSLVSG LVSMTNPPAS SSSAPSPAAS 180
SASASQSPPL SCAVPSNDSS PIYSAAPTFP TPNTDIFPEP QSQAFPGSAG TALQYPPPAY 240
PAAKGGFQVP MIPDYLFPQQ QGDLGLGTPD QKPFQGLESR TQQPSLTPLS TIKAFATQSG 300
SQDLKALNTS YQSQLIKPSR MRKYPNRPSK TPPHERPYAC PVESCDRRFS RSDELTRHIR 360
IHTGQKPFQC RICMRNFSRS DHLTTHIRTH TGEKPFACDI CGRKFARSDE RKRHTKIHLR 420
QKDKKADKSV VASSATSSLS SYPSPVATSY PSPVTTSYPS PATTSYPSPV PTSFSSPGSS 480
TYPSPVHSGF PSPSVATTYS SVPPAFPAQV SSFPSSAVTN SFSASTGLSD MTATFSPRTI 540
EIC 543 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0071236; P:cellular response to antibiotic; IEA:Compara.
 GO:0071320; P:cellular response to cAMP; IEA:Compara.
 GO:0035690; P:cellular response to drug; IEA:Compara.
 GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Compara.
 GO:0071480; P:cellular response to gamma radiation; IEA:Compara.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0071504; P:cellular response to heparin; ISS:UniProtKB.
 GO:0071455; P:cellular response to hyperoxia; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0071317; P:cellular response to isoquinoline alkaloid; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
 GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
 GO:0071383; P:cellular response to steroid hormone stimulus; IEA:Compara.
 GO:0007623; P:circadian rhythm; IEA:Compara.
 GO:0072110; P:glomerular mesangial cell proliferation; ISS:UniProtKB.
 GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:BHF-UCL.
 GO:0007611; P:learning or memory; IEA:Compara.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0048709; P:oligodendrocyte differentiation; IEA:Compara.
 GO:0072303; P:positive regulation of glomerular metanephric mesangial cell proliferation; ISS:UniProtKB.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Compara.
 GO:0033233; P:regulation of protein sumoylation; IDA:BHF-UCL.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0034465; P:response to carbon monoxide; IEA:Compara.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0051602; P:response to electrical stimulus; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0071873; P:response to norepinephrine stimulus; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0030217; P:T cell differentiation; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 
Interpro
 IPR021839; DUF3432.
 IPR021849; DUF3446.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF11914; DUF3432
 PF11928; DUF3446
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS