UniProt Accession

 F8VW29_HUMAN; F8VW29 

Genbank Protein ID

 AC024909 

Genbank Nucleotide ID

  

Protein Name

 Dual-specificity protein phosphatase 6 

Protein Synonyms/Alias

  

Gene Name

 DUSP6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
129	FENAGEFKYKQIPIS	ubiquitination	[1, 2]
199	NDAYDIVKMKKSNIS	ubiquitination	[1, 2]
202	YDIVKMKKSNISPNF	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 256 AA 

Protein Sequence

Gene Ontology

 GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
 GO:0006470; P:protein dephosphorylation; IEA:InterPro. 

Interpro

 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR008343; MKP.
 IPR000387; Tyr/Dual-sp_Pase. 

Pfam

 PF00782; DSPc 

SMART

 SM00195; DSPc 

PROSITE

 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 

PRINTS

 PR01764; MAPKPHPHTASE.