UniProt Accession

 MZB1_HUMAN; Q8WU39; D2IYS0; Q7Z6N2; Q96RL5; Q9P0T3 

Genbank Protein ID

 AF338109; AF151024; BP366737; GQ477350; AK292706; AL698690; AC135457; BC009931; BC021275 

Genbank Nucleotide ID

 AAK84085.1; AAF36110.1; ACY74343.1; BAF85395.1; AAH09931.2; AAH21275.1 

Protein Name

 Marginal zone B- and B1-cell-specific protein 

Protein Synonyms/Alias

 Mesenteric estrogen-dependent adipose 7; MEDA-7; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; pERp1; Proapoptotic caspase adapter protein 

Gene Name

 MZB1 

Gene Synonyms/Alias

 MEDA7; PACAP; HSPC190 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	QMWQNLAKAETKLHT	ubiquitination	[1]
70	NLAKAETKLHTSNSG	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. 

Sequence Annotation

 MOTIF 186 189 Prevents secretion from ER (Potential).
 DISULFID 50 178 By similarity.
 DISULFID 53 171 By similarity.
 DISULFID 95 143 By similarity.  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Disulfide bond; Endoplasmic reticulum; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0034663; C:endoplasmic reticulum chaperone complex; ISS:UniProtKB.
 GO:0005788; C:endoplasmic reticulum lumen; ISS:UniProtKB.
 GO:0005576; C:extracellular region; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0033622; P:integrin activation; ISS:UniProtKB.
 GO:2001274; P:negative regulation of glucose import in response to insulin stimulus; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:0002642; P:positive regulation of immunoglobulin biosynthetic process; ISS:UniProtKB.
 GO:0030888; P:regulation of B cell proliferation; ISS:UniProtKB. 

Interpro

 IPR021852; DUF3456. 

Pfam

 PF11938; DUF3456 

SMART

  

PROSITE

 PS00014; ER_TARGET 

PRINTS