UniProt Accession

 UPP_YEAST; P18562; D3DL77 

Genbank Protein ID

 M36485; S57516; X79811; U10398; AY693082; BK006934 

Genbank Nucleotide ID

 AAA34611.1; AAB19947.2; CAA56207.1; AAB68405.1; AAT93101.1; DAA06821.1 

Protein Name

 Uracil phosphoribosyltransferase 

Protein Synonyms/Alias

 UPRTase; UMP pyrophosphorylase 

Gene Name

 FUR1 

Gene Synonyms/Alias

 YHR128W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
123	LPKLFYEKLPEDISE	acetylation	[1]
123	LPKLFYEKLPEDISE	ubiquitination	[2]
177	CSKEGIEKYHAAFPE	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. 

Sequence Annotation

 REGION 137 145 5-phospho-alpha-D-ribose 1-diphosphate
 REGION 207 209 Uracil binding (By similarity).
 BINDING 41 41 GTP (By similarity).
 BINDING 77 77 GTP (By similarity).
 BINDING 85 85 5-phospho-alpha-D-ribose 1-diphosphate
 BINDING 102 102 GTP (By similarity).
 BINDING 110 110 5-phospho-alpha-D-ribose 1-diphosphate
 BINDING 131 131 GTP (By similarity).
 BINDING 137 137 5-phospho-alpha-D-ribose 1-diphosphate
 BINDING 201 201 Ribose-5-phosphate (By similarity).
 BINDING 202 202 Uracil; via amide nitrogen (By
 BINDING 208 208 5-phospho-alpha-D-ribose 1-diphosphate
 MOD_RES 82 82 Phosphoserine.  

Keyword

 Allosteric enzyme; Complete proteome; Glycosyltransferase; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 216 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IC:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004845; F:uracil phosphoribosyltransferase activity; IDA:SGD.
 GO:0008655; P:pyrimidine-containing compound salvage; IDA:SGD.
 GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway. 

Interpro

  

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