CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018132
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Retinol dehydrogenase 10 
Protein Synonyms/Alias
  
Gene Name
 Rdh10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
268EPFLPPLKPDYCVKQubiquitination[1]
319YRFLGADKCMYPFIAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). Required for normal embryonic development. 
Sequence Annotation
 NP_BIND 40 64 NADP (By similarity).
 ACT_SITE 210 210 Proton acceptor (By similarity).
 BINDING 197 197 Substrate (By similarity).  
Keyword
 Complete proteome; Endoplasmic reticulum; Membrane; Microsome; NADP; Oxidoreductase; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 341 AA 
Protein Sequence
MNIVVEFFVV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR LFALEFARRR 60
ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGKG EEEILPPCNL QVFTYTCDVG 120
KRENVYLTAE RVRKEVGEVS VLVNNAGVVS GHHLLECPDE LIERTMMVNC HAHFWTTKAF 180
LPTMLEINHG HIVTVASSLG LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL 240
VCPYLVDTGM FRGCRIRKEI EPFLPPLKPD YCVKQAMRAI LTDQPMVCTP RLMYIVTFMK 300
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I 341 
Gene Ontology
 GO:0044297; C:cell body; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0052650; F:NADP-retinol dehydrogenase activity; IEA:EC.
 GO:0004745; F:retinol dehydrogenase activity; IMP:MGI.
 GO:0060449; P:bud elongation involved in lung branching; IMP:MGI.
 GO:0043583; P:ear development; IMP:MGI.
 GO:0031076; P:embryonic camera-type eye development; IMP:MGI.
 GO:0035115; P:embryonic forelimb morphogenesis; IMP:MGI.
 GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:MGI.
 GO:0008406; P:gonad development; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0001656; P:metanephros development; IMP:MGI.
 GO:0014032; P:neural crest cell development; IMP:MGI.
 GO:0043584; P:nose development; IMP:MGI.
 GO:0060431; P:primary lung bud formation; IMP:MGI.
 GO:0042574; P:retinal metabolic process; IEA:Compara.
 GO:0002138; P:retinoic acid biosynthetic process; IMP:MGI.
 GO:0042572; P:retinol metabolic process; IEA:UniProtKB-UniPathway.
 GO:0007601; P:visual perception; ISA:MGI. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.