CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022922
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable ribosome biogenesis protein RLP24 
Protein Synonyms/Alias
 Ribosomal L24 domain-containing protein 1; Ribosomal protein L24-like 
Gene Name
 RSL24D1 
Gene Synonyms/Alias
 C15orf15; RPL24L; My024 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***MRIEKCYFCSGPubiquitination[1]
27MFVRNDCKVFRFCKSubiquitination[1]
53PRKVRWTKAFRKAAGubiquitination[1]
61AFRKAAGKELTVDNSubiquitination[1]
73DNSFEFEKRRNEPIKubiquitination[1, 2]
80KRRNEPIKYQRELWNubiquitination[1]
88YQRELWNKTIDAMKRubiquitination[1]
94NKTIDAMKRVEEIKQubiquitination[1]
106IKQKRQAKFIMNRLKubiquitination[1, 3, 4]
120KKNKELQKVQDIKEVubiquitination[1, 5]
125LQKVQDIKEVKQNIHubiquitination[2, 5]
128VQDIKEVKQNIHLIRubiquitination[1, 2, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 163 AA 
Protein Sequence
MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR WTKAFRKAAG 60
KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK QKRQAKFIMN RLKKNKELQK 120
VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV QQLQEDVDME DAP 163 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR023442; Ribosomal_L24e_CS.
 IPR023441; Ribosomal_L24e_dom.
 IPR000988; Ribosomal_L24e_rel.
 IPR024546; Ribosome_biogen_RLP24.
 IPR011017; TRASH_dom. 
Pfam
 PF01246; Ribosomal_L24e 
SMART
 SM00746; TRASH 
PROSITE
 PS01073; RIBOSOMAL_L24E 
PRINTS