CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024375
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho guanine nucleotide exchange factor 10-like protein 
Protein Synonyms/Alias
 GrinchGEF 
Gene Name
 Arhgef10l 
Gene Synonyms/Alias
 Kiaa1626 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
217KERYVRTKRDILALRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC (By similarity). 
Sequence Annotation
 DOMAIN 314 501 DH.
 MOD_RES 131 131 Phosphotyrosine.
 MOD_RES 152 152 Phosphotyrosine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1280 AA 
Protein Sequence
MASSNPPPQP AIGAPLAPSA PGPSPEVEED SGEAFEFDDS DEEEDTSSGL VVPGLAPERD 60
TEPSLICFDT VPGSDLDPAA APPQTEAPTV VSNGDAVGAA ISGVRRSSWK RKSSRRIDRF 120
TFPALEEDVI YDDVPCESPD AHQPGAERGL VYEDVHRAGA PRETEDLGWS SSEFESYSED 180
SGEETKPEAE PTKHRGSFQP KLSPDLTRLK ERYVRTKRDI LALRVGGRDM QELKLKCDCK 240
MTQLMKAAKS GTRDGLEKTR MAVMRKVSFL HRKDVLGDSE EEDMGLLEVG VTDIKPPAPE 300
LGPMPDGLSP QQVVRRHILG SIVQSEGSYV ESLKRILQDY RNPLMEMEPK ALSARKCQVV 360
FFRVKEILHC HSMFQIALSS RVAEWDSTEK IGDLFVASFS KSMVLDVYSD YVNNFTNAMS 420
IIKKACLTKP AFLEFLKRRQ VCSTDRVTLY GLMVKPVQRF PQFILLLQDM LKNTPRGHPD 480
RLSLQLALTE LETLAEKLNE QKRLADQVAE IQQLTKSVSD RSSLNKLLTS GQRQLLLCET 540
LTETVYGDRG QLIKSKERRV FLLNDMLVCA NINFKPSNHR GQLEISSLVP LGPKYVVKWN 600
TALPQVQVVE VGQDGGTYDK DNLLIQHAGA KKATAAGQAQ NKVYLGPPRL FQELQDLQKD 660
LAVVEQITLL ISTLHGTYQN LNMTVAQDWC LALQRLMRVK EEEIHSANKC RLRLLLPGKP 720
DKSGRPISFM VVFITPNPLS KISWVNRLHL AKIGLREENQ PGWLCPDEDK KSKAPFWCPI 780
LACCVPAFSS RTLSLQLGGL VHSPVNSPLL GFSAVSTSLP QGYLWVGGGQ EGAGGQVEIF 840
SLNRPSPRTV KSFPVAAPVL CIEYIPDPEE EAEGAEESRA ATDPSVTVHP TVCLGLQDGS 900
ILLYGSVDTG TQCLATCKSP GPQPVLCLRH SPFYLLAGLQ DGTLAAYPRT SGDIPWDLES 960
PPMCITVGPG PIRTLLSLED AAWASCGPRV TVLDAATLQT QQSFEAHQDE AVSVTHMVKA 1020
GSGVWMAFSS GSSIRLFHTE TLEHLQEINI ATRTTFLLPG QKHLCVTSLL ICQGLLWVGT 1080
DQGVIVLLPV PRLEGIPKIT GKGMVSLNGH CGPVAFLAVA MSILAPDILR SDQEEAEGPQ 1140
AEEDKPDGQA HETVPGPDSH TARELTRKKG ILLQYRLRST AHLPGPLLSV REPAPADGSA 1200
LEHSEEDGSI YEMADDPDVW VRSRPCARDA HRKEICSVAI ISGGQGYRHF GGAPGGLSGR 1260
AAPCSETDST LLIWQVPLAL 1280 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00621; RhoGEF 
SMART
 SM00325; RhoGEF 
PROSITE
 PS00741; DH_1
 PS50010; DH_2 
PRINTS