| Tag | Content |
|---|
| CPLM ID | CPLM-043490 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 3 subunit C |
Protein Synonyms/Alias | eIF3c; Eukaryotic translation initiation factor 3 subunit 8; eIF3 p110 |
Gene Name | EIF3C |
Gene Synonyms/Alias | EIF3S8 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 277 | KKHDRKSKRLDEEEE | acetylation | [1] |
|
Reference | [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C. PLoS One. 2012;7(12):e50545. [ PMID: 23236377] |
Functional Description | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity). |
Sequence Annotation | DOMAIN 703 836 PCI (By similarity).
MOD_RES 9 9 Phosphoserine (By similarity).
MOD_RES 11 11 Phosphoserine (By similarity).
MOD_RES 13 13 Phosphoserine (By similarity).
MOD_RES 15 15 Phosphoserine (By similarity).
MOD_RES 16 16 Phosphoserine (By similarity).
MOD_RES 18 18 Phosphoserine (By similarity).
MOD_RES 39 39 Phosphoserine (By similarity).
MOD_RES 156 156 Phosphoserine (By similarity).
MOD_RES 514 514 Phosphothreonine (By similarity). |
Keyword | Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 903 AA |
Protein Sequence | MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR SAKDKRFEEL 60
TNLIRTIRNA MKIRDVTKCL EEFELLGKAY GKAKSIVDKE GVPRFYIRIL ADLEDYLNEM 120
NKNNAKALST LRQKIRKYNR DFESHITSYK QNPEQSADED AEKNEEDSEG SSDEDEDEDG 180
VSAATFLKKK SEAPSGESRK FLKKMDDEDE DSEDSEDDED WDTGSTSSDS DSEEEEGKQT 240
ALASRFLKKA PTTDEDKKAA EKKREDKAKK KHDRKSKRLD EEEEDNEGGE WERVRGGVPL 300
VKEKPKMFAK GTEITHAVVI KKLNEILQAR GKKGTDRAAQ IELLQLLVQI AAENNLGEGV 360
IVKIKFNIIA SLYDYNPNLA TYMKPEMWGK CLDCINELMD ILFANPNIFV GENILEESEN 420
LHNADQPLRV RGCILTLVER MDEEFTKIMQ NTDPHSQEYV EHLKDEAQVC AIIERVQRYL 480
EEKGTTEEVC RIYLLRILHT YYKFDYKAHQ RQLTPPEGSS KSEQDQAENE GEDSAVLMER 540
LCKYIYAKDR TDRIRTCAIL CHIYHHALHS RWYQARDLML MSHLQDNIQH ADPPVQILYN 600
RTMVQLGICA FRQGLTKDAH NALLDIQSSG RAKELLGQGL LLRSLQERNQ EQEKVERRRQ 660
VPFHLHINLE LLECVYLVSA MLLEIPYMAA HESDARRRMI SKQFHHQLRV GERQPLLGPP 720
ESMREHVVAA SKAMKMGDWK TCHSFIINEK MNGKVWDLFP EADKVRTMLV RKIQEESLRT 780
YLFTYSSVYD SISMETLSDM FELDLPTVHS IISKMIINEE LMASLDQPTQ TVVMHRTEPT 840
AQQNLALQLA EKLGSLVENN ERVFDHKQGT YGGYFRDQKD GYRKNEGYMR RGGYRQQQSQ 900
TAY 903 |
Gene Ontology | GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP. GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP. GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:HAMAP. GO:0003743; F:translation initiation factor activity; IEA:HAMAP. GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP. GO:0006446; P:regulation of translational initiation; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |