CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013880
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GMP synthase [glutamine-hydrolyzing] 
Protein Synonyms/Alias
 GMP synthetase; Glutamine amidotransferase 
Gene Name
 guaA 
Gene Synonyms/Alias
 TTHA1552 
Created Date
 July 27, 2013 
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 
NCBI Taxa ID
 300852 
Lysine Modification
Position
Peptide
Type
References
359EPFRLLFKDEVRELAacetylation[1]
Reference
 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 
Functional Description
 Catalyzes the synthesis of GMP from XMP (By similarity). 
Sequence Annotation
 DOMAIN 1 189 Glutamine amidotransferase type-1.
 DOMAIN 190 378 GMPS ATP-PPase.
 NP_BIND 217 223 ATP (By similarity).
 ACT_SITE 78 78 Nucleophile (By similarity).
 ACT_SITE 164 164 By similarity.
 ACT_SITE 166 166 By similarity.  
Keyword
 3D-structure; ATP-binding; Complete proteome; Glutamine amidotransferase; GMP biosynthesis; Ligase; Nucleotide-binding; Purine biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 503 AA 
Protein Sequence
MVLVLDFGSQ YTRLIARRLR ELRAFSLILP GDAPLEEVLK HRPQALILSG GPRSVFDPDA 60
PRPDPRLFSS GLPLLGICYG MQLLAQELGG RVERAGRAEY GKALLTRHEG PLFRGLEGEV 120
QVWMSHQDAV TAPPPGWRVV AETEENPVAA IASPDGRAYG VQFHPEVAHT PKGMQILENF 180
LELAGVKRDW TPEHVLEELL REVRERAGKD RVLLAVSGGV DSSTLALLLA KAGVDHLAVF 240
VDHGLLRLGE REEVEGALRA LGVNLLVVDA KERFLKALKG VEDPEEKRKI IGREFVAAFS 300
QVARERGPFR FLAQGTLYPD VIESAGGHGA AKIKSHHNVG GLPEDLEFEL LEPFRLLFKD 360
EVRELALLLG LPDTLRLRHP FPGPGLAVRV LGEVTEERLE ILRRADDIFT SLLREWGLYE 420
KVAQALAVLT PVRSVGVAGD ERKYGYVLAL RAVTTEDFMT ADWARLPLEF LDEAARRITR 480
RVPEIGRVVY DLTSKPPATI EWE 503 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0003922; F:GMP synthase (glutamine-hydrolyzing) activity; IEA:HAMAP.
 GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
 GO:0006541; P:glutamine metabolic process; IEA:HAMAP.
 GO:0006177; P:GMP biosynthetic process; IEA:HAMAP. 
Interpro
 IPR017926; GATASE.
 IPR001674; GMP_synth_C.
 IPR004739; GMP_synth_N.
 IPR022955; GMP_synthase.
 IPR025777; GMPS_ATP_PPase_dom.
 IPR014729; Rossmann-like_a/b/a_fold. 
Pfam
 PF00117; GATase
 PF00958; GMP_synt_C 
SMART
  
PROSITE
 PS51273; GATASE_TYPE_1
 PS51553; GMPS_ATP_PPASE 
PRINTS