UniProt Accession

 VDAC2_MOUSE; Q60930; Q78MH6; Q99L98 

Genbank Protein ID

 U30838; AK168199; AK159561; AK152274; AK150940; AK150627; AK150504; AK012359; AY294423; BC003731 

Genbank Nucleotide ID

 AAC13321.1; BAE40159.1; BAE35185.1; BAE31090.1; BAE29975.1; BAE29717.1; BAE29617.1; BAE43231.1; AAQ01516.1; AAH03731.2 

Protein Name

 Voltage-dependent anion-selective channel protein 2 

Protein Synonyms/Alias

 VDAC-2; mVDAC2; Outer mitochondrial membrane protein porin 2; Voltage-dependent anion-selective channel protein 6; VDAC-6; mVDAC6 

Gene Name

 Vdac2 

Gene Synonyms/Alias

 Vdac6 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	PPYADLGKAARDIFN	ubiquitination	[1]
32	AARDIFNKGFGFGLV	acetylation	[2, 3]
32	AARDIFNKGFGFGLV	ubiquitination	[1]
40	GFGFGLVKLDVKTKS	acetylation	[3]
40	GFGFGLVKLDVKTKS	ubiquitination	[1]
65	SSNTDTGKVSGTLET	ubiquitination	[1]
73	VSGTLETKYKWCEYG	ubiquitination	[1]
75	GTLETKYKWCEYGLT	acetylation	[2, 3]
75	GTLETKYKWCEYGLT	ubiquitination	[1]
121	TFSPNTGKKSGKIKS	ubiquitination	[1]
278	LSALVDGKSFNAGGH	ubiquitination	[1]
286	SFNAGGHKLGLALEL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective (By similarity). 

Sequence Annotation

 NP_BIND 254 256 NAD (By similarity).
 NP_BIND 272 276 NAD (By similarity).
 MOD_RES 32 32 N6-acetyllysine.
 MOD_RES 75 75 N6-acetyllysine.
 MOD_RES 207 207 Phosphotyrosine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Nucleotide-binding; Phosphoprotein; Porin; Reference proteome; Transmembrane; Transmembrane beta strand; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0042645; C:mitochondrial nucleoid; IEA:Compara.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0046930; C:pore complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0015288; F:porin activity; IEA:UniProtKB-KW.
 GO:0008308; F:voltage-gated anion channel activity; IEA:InterPro.
 GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:0032272; P:negative regulation of protein polymerization; IMP:UniProtKB. 

Interpro

 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 

Pfam

 PF01459; Porin_3 

SMART

  

PROSITE

 PS00558; EUKARYOTIC_PORIN 

PRINTS

 PR00185; EUKARYTPORIN.