| Tag | Content |
|---|
| CPLM ID | CPLM-014430 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Apoptosis-stimulating of p53 protein 1 |
Protein Synonyms/Alias | Protein phosphatase 1 regulatory subunit 13B |
Gene Name | Ppp1r13b |
Gene Synonyms/Alias | Aspp1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 288 | LNQEQNSKLQQQKEL | ubiquitination | [1] | | 1049 | AITILRRKDENETEW | ubiquitination | [1] | | 1070 | DREGYVPKNLLGLYP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity). |
Sequence Annotation | REPEAT 917 949 ANK 1.
REPEAT 950 982 ANK 2.
DOMAIN 1016 1078 SH3.
MOD_RES 332 332 Phosphoserine.
MOD_RES 335 335 Phosphoserine.
MOD_RES 669 669 Phosphoserine.
MOD_RES 679 679 Phosphoserine (By similarity). |
Keyword | ANK repeat; Apoptosis; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1087 AA |
Protein Sequence | MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GGCHLAEVWR GSERPIPYDH 60
MMYEHLQKWG PRREEVKFFL RHEDSPTESS EQGARQTQEQ RTQRSVVNVP GEKRTENGVG 120
NPRVELTLSE LQDMAARQQQ QIENQQQMLV AKEQRLHFLK QQERRQQQSV SENEKLQKLK 180
ERVEAQENKL KKIRAMRGQV DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ 240
QLEDLKKGKL NGFQSYNGRL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN 300
MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI QVPSTGGFPL 360
PGDPVKPQSL TIASSAAHGR SKSANDGNWP PLKQNSASVK STQMTGDWKD SGMEGTLKQG 420
AISSQPLPLS ALGATEKLGI EIGKGPPPIP GVGKPLPPSY GTYPSSGPLG PGSTSSLERR 480
KEGSLPRPGA GPPSRQKPAP LPPASNAPQP GSSQQIQQRI SVPPSPTYPP AGPPAFPTGD 540
GKPELPLTVA IRPFLADKGS RPQSPRKGPQ TVNSSSIYSM YLQQATPPKN YQPPAHGTLN 600
KSVKAVYGKP VLPSGSASPS PLPFLHGSLG TGTAQPQPPS DSAEKEPEQE GPSVPGEGST 660
VESLPRPLSP TKLTPIVHSP LRYQSDADLE ALRRKLANAP RPLKKRSSIT EPEGPGGPNI 720
QKLLYQRFNT LAGGMEGTPF YQPSPSQDFV GTLADMDNGN TNANGNLDEP FPPRPTAPLP 780
EELAPSSDAN DNELPSPEPE ELICPQTTHQ TAEPTEDNNN NVAPVPSTEQ IPSPVAEAPS 840
EEDQVPPAPL SPVIHPPAAS ASKRTNLKKP NSERTGHGLR VRFNPLALLL DASLEGEFDL 900
VQRIIYEVED PSKPNDEGIT PLHNAVCAGH HHIVKFLLDF GVNVNAADSD GWTPLHCAAS 960
CNSVHLCKQL VESGAAIFAS TISDIETAAD KCEEMEEGYI QCSQFLYGVQ EKLGVMNKGT 1020
VYALWDYEAQ NSDELSFHEG DAITILRRKD ENETEWWWAR LGDREGYVPK NLLGLYPRIK 1080
PRQRTLA 1087 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |