UniProt Accession

 GIMA7_HUMAN; Q8NHV1 

Genbank Protein ID

 BC027613 

Genbank Nucleotide ID

 AAH27613.1 

Protein Name

 GTPase IMAP family member 7 

Protein Synonyms/Alias

 Immunity-associated nucleotide 7 protein; IAN-7 

Gene Name

 GIMAP7 

Gene Synonyms/Alias

 IAN7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
16	LRIVLVGKTGSGKSA	ubiquitination	[1, 2]
21	VGKTGSGKSATANTI	ubiquitination	[1, 2]
45	IAAQAVTKNCQKASR	ubiquitination	[1, 2, 3]
49	AVTKNCQKASREWQG	ubiquitination	[1]
71	TPGLFDTKESLDTTC	ubiquitination	[1, 2]
79	ESLDTTCKEISRCII	ubiquitination	[2]
110	RYTEEEQKTVALIKA	ubiquitination	[2]
121	LIKAVFGKSAMKHMV	ubiquitination	[1]
154	ADADVGLKSIVKECG	ubiquitination	[1]
158	VGLKSIVKECGNRCC	ubiquitination	[1, 2]
175	SNSKKTSKAEKESQV	ubiquitination	[1]
178	KKTSKAEKESQVQEL	ubiquitination	[1]
207	YFSDDIYKDTEERLK	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 The dimer has GTPase activity; the active site contains residues from both subunits. 

Sequence Annotation

 NP_BIND 15 23 GTP.
 NP_BIND 133 135 GTP.
 BINDING 36 36 GTP.
 BINDING 169 169 GTP.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; GTP-binding; Lipid droplet; Nucleotide-binding; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0005811; C:lipid particle; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IDA:UniProtKB. 

Interpro

 IPR006703; AIG1.
 IPR027417; P-loop_NTPase. 

Pfam

 PF04548; AIG1 

SMART

  

PROSITE

  

PRINTS