UniProt Accession

 CNR1_HUMAN; P21554; B2R9T4; E1P512; Q13949; Q495Z0; Q4PLI4; Q4VBM6; Q5JVL5; Q5UB37; Q9UNN0 

Genbank Protein ID

 X54937; X81120; X81121; AY766182; AF107262; U73304; DQ067455; AY225225; AL136096; AL136096; AK313908; CH471051; CH471051; CH471051; BC074811; BC074812; BC095513; BC100968; BC100969; BC100970; BC100971 

Genbank Nucleotide ID

 CAA38699.1; CAA57018.1; CAA57019.1; AAV35030.1; AAD34320.1; AAB18200.1; AAY68486.1; AAO67710.1; CAB96726.1; CAI19916.1; BAG36631.1; EAW48574.1; EAW48575.1; EAW48576.1; AAH74811.1; AAH74812.1; AAH95513.1; AAI00969.1; AAI00970.1; AAI00971.1; AAI00972.1 

Protein Name

 Cannabinoid receptor 1 

Protein Synonyms/Alias

 CB-R; CB1; CANN6 

Gene Name

 CNR1 

Gene Synonyms/Alias

 CNR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
402	IIYALRSKDLRHAFR	acetylation	[1]

Reference

 [1] Regulation of Gi by the CB1 cannabinoid receptor C-terminal juxtamembrane region: structural requirements determined by peptide analysis.
 Mukhopadhyay S, Cowsik SM, Lynn AM, Welsh WJ, Howlett AC.
 Biochemistry. 1999 Mar 16;38(11):3447-55. [PMID: 10079092] 

Functional Description

 Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. 

Sequence Annotation

 LIPID 415 415 S-palmitoyl cysteine.
 CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
 CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
 CARBOHYD 112 112 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 472 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004949; F:cannabinoid receptor activity; IDA:UniProtKB.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IDA:UniProtKB.
 GO:0007568; P:aging; IEA:Compara.
 GO:0007610; P:behavior; TAS:ProtInc.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:0007613; P:memory; IEA:Compara.
 GO:0045759; P:negative regulation of action potential; IEA:Compara.
 GO:0045776; P:negative regulation of blood pressure; IEA:Compara.
 GO:0033602; P:negative regulation of dopamine secretion; IEA:Compara.
 GO:0031999; P:negative regulation of fatty acid beta-oxidation; IEA:Compara.
 GO:0033004; P:negative regulation of mast cell activation; IEA:Compara.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0002866; P:positive regulation of acute inflammatory response to antigenic stimulus; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0045777; P:positive regulation of blood pressure; IEA:Compara.
 GO:0031622; P:positive regulation of fever generation; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0060259; P:regulation of feeding behavior; IEA:Compara.
 GO:0050796; P:regulation of insulin secretion; IEA:Compara.
 GO:0060405; P:regulation of penile erection; IEA:Compara.
 GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Compara.
 GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Compara.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0043278; P:response to morphine; IEA:Compara.
 GO:0035094; P:response to nicotine; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0006950; P:response to stress; IEA:Compara.
 GO:0019233; P:sensory perception of pain; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR002230; Cnbnoid_rcpt.
 IPR000810; Cnoid_rcpt_1.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00522; CANABINOID1R.
 PR00362; CANNABINOIDR.
 PR00237; GPCRRHODOPSN.