| Tag | Content |
|---|
| CPLM ID | CPLM-018491 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Anaphase-promoting complex subunit 4 |
Protein Synonyms/Alias | APC4; Cyclosome subunit 4 |
Gene Name | Anapc4 |
Gene Synonyms/Alias | D5Ertd249e |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 147 | PKLPTLPKNYNSTSK | ubiquitination | [1] | | 328 | LMNQLTVKGLKKLGQ | ubiquitination | [1] | | 332 | LTVKGLKKLGQSIES | ubiquitination | [1] | | 468 | DLYNRKGKYFNVERV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). |
Sequence Annotation | MOD_RES 469 469 Phosphotyrosine (By similarity).
MOD_RES 757 757 Phosphoserine (By similarity).
MOD_RES 758 758 Phosphoserine (By similarity).
MOD_RES 777 777 Phosphoserine (By similarity).
MOD_RES 779 779 Phosphoserine (By similarity). |
Keyword | Cell cycle; Cell division; Complete proteome; Mitosis; Phosphoprotein; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 807 AA |
Protein Sequence | MLRFPTCFPS FRVVGEKQLP QEIIFLAWSP KRDLIALANT TGEVLLHRLA SFHRVWSFPP 60
NESTGKEVTC LAWRPDGKLL AFALADTKKI ILCDVEKPES LHSFSVEAPV SCMHWTEVTV 120
ESSVLTSFYN AEDESNLLLP KLPTLPKNYN STSKIFSEEN SDEIIKLLGD VRLNILVLGG 180
SSGFIELYAY GMFKIARVTG IAGTCIALCL SSDLKSLSVV TEVSSGGESE VSYFQLETNL 240
LYSFLPEVTR MARKFTHISA LLQYINLSLT CMCEAWEEIL MQMDSRLTKF VQEKPTTTSV 300
QDEFMHLLLW GKASAELQTL LMNQLTVKGL KKLGQSIESS YSSIQKLVIS HLQSGSESLL 360
YHLSELKGMA SWKQKYEPLG LDAAGIEDAI TAVGSFILKA NELLQVIDSS MKNFKAFFRW 420
LYVAMLRMTE DHVLPELNKM TQKDITFVAE FLTEHFNEAP DLYNRKGKYF NVERVGQYLK 480
DEDDDLVSPP NTEGNQWYDF LQNSTHLKES PLLFPYYPRK SLHFVKRRME NVIDQCLQKP 540
ADVIGRSMNQ AICIPLYKDA RSMDCARRLL KFPFLWNNKT SNLHYLLFTI LEDSVYKMCI 600
LRRHTDISQS VSNGLIGIKF GSFTSASADK VRRSSYSCLD AQFYDDETVT VILKDSMGRE 660
GRDRILVQLS LSLVYNSEDS DEYEFTGSYS TRLDEQGSII PTRTMHFEKH WRLLESMRAQ 720
YVAGNGLRKV SCVLSSNLRH VRVFEMDIDD EWEIDESSDD EEEAGGKPVK IKEEVLSESE 780
TEAHQDAAAL DPDVVIKVEK LDPELDS 807 |
Gene Ontology | GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB. GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB. GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |