UniProt Accession

 DIM1_YEAST; P41819; D6W3A4 

Genbank Protein ID

 L26480; Z73622; BK006949 

Genbank Nucleotide ID

 AAA57357.1; CAA98001.1; DAA11170.1 

Protein Name

 Dimethyladenosine transferase 

Protein Synonyms/Alias

 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; 18S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 

Gene Name

 DIM1 

Gene Synonyms/Alias

 YPL266W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
16	YSGATSSKQVSAEKH	acetylation	[1]
22	SKQVSAEKHLSSVFK	acetylation	[1]
40	DLGQHILKNPLVAQG	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. 

Sequence Annotation

 BINDING 37 37 S-adenosyl-L-methionine; via carbonyl
 BINDING 39 39 S-adenosyl-L-methionine; via amide
 BINDING 64 64 S-adenosyl-L-methionine; via carbonyl
 BINDING 85 85 S-adenosyl-L-methionine (By similarity).
 BINDING 113 113 S-adenosyl-L-methionine (By similarity).
 BINDING 128 128 S-adenosyl-L-methionine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Methyltransferase; Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0030686; C:90S preribosome; IDA:SGD.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; TAS:SGD.
 GO:0052909; F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity; IEA:EC.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000179; F:rRNA (adenine-N6,N6-)-dimethyltransferase activity; NAS:UniProtKB. 

Interpro

 IPR025814; DIM1.
 IPR020596; rRNA_Ade_Mease_Trfase_CS.
 IPR001737; rRNA_Ade_methylase_transferase.
 IPR020598; rRNA_Ade_methylase_Trfase_N.
 IPR011530; rRNA_adenine_dimethylase. 

Pfam

 PF00398; RrnaAD 

SMART

 SM00650; rADc 

PROSITE

 PS01131; RRNA_A_DIMETH 

PRINTS