UniProt Accession

 TF2H3_MOUSE; Q8VD76 

Genbank Protein ID

 BC017515 

Genbank Nucleotide ID

 AAH17515.1 

Protein Name

 General transcription factor IIH subunit 3 

Protein Synonyms/Alias

 Basic transcription factor 2 34 kDa subunit; BTF2 p34; General transcription factor IIH polypeptide 3; TFIIH basal transcription factor complex p34 subunit 

Gene Name

 Gtf2h3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
126	LMTKSDIKGQHTETL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB (By similarity). 

Sequence Annotation

 ZN_FING 269 286 C4-type.  

Keyword

 Complete proteome; DNA damage; DNA repair; Metal-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 309 AA 

Protein Sequence

Gene Ontology

 GO:0000439; C:core TFIIH complex; IEA:InterPro.
 GO:0005675; C:holo TFIIH complex; ISS:UniProtKB.
 GO:0008094; F:DNA-dependent ATPase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:Compara.
 GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006366; P:transcription from RNA polymerase II promoter; ISS:UniProtKB. 

Interpro

 IPR004600; TFIIH_Tfb4/p34. 

Pfam

 PF03850; Tfb4 

SMART

  

PROSITE

  

PRINTS