CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009790
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosomal large subunit pseudouridine synthase D 
Protein Synonyms/Alias
 23S rRNA pseudouridine(1911/1915/1917) synthase; rRNA pseudouridylate synthase D; rRNA-uridine isomerase D 
Gene Name
 rluD 
Gene Synonyms/Alias
 sfhB; STM2662 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
54VNGQLCDKPKEKVLGacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA (By similarity). 
Sequence Annotation
 DOMAIN 18 91 S4 RNA-binding.
 ACT_SITE 139 139 By similarity.  
Keyword
 Complete proteome; Isomerase; Reference proteome; RNA-binding; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 326 AA 
Protein Sequence
MAQRVQLTAT VSENQLGQRL DQALAEMFPD YSRSRIKEWI LNQRVLVNGQ LCDKPKEKVL 60
GGERVAIDAE IDEEIRFEAQ DIPLDIVYED DDILVINKPR DLVVHPGAGN PDGTVLNALL 120
HYYPPIADVP RAGIVHRLDK DTTGLMVVAK TVPAQTRLVE SLQLREITRE YEAVAIGHMT 180
AGGTVNEPIS RHPTKRTHMS VHPMGKPAVT HYRIMEHFRV HTRLRLRLET GRTHQIRVHM 240
AHITHPLVGD QVYGGRPRPP KGASEEFIST LRKFDRQALH ATMLRLYHPV SGIEMEWHAP 300
IPQDMVDLID AMRADFEDHK DDVDWL 326 
Gene Ontology
 GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR020103; PsdUridine_synth_cat_dom.
 IPR006225; PsdUridine_synth_RluC/D.
 IPR006224; PsdUridine_synth_RluC/D_CS.
 IPR006145; PsdUridine_synth_RsuA/RluD.
 IPR002942; S4_RNA-bd. 
Pfam
 PF00849; PseudoU_synth_2
 PF01479; S4 
SMART
 SM00363; S4 
PROSITE
 PS01129; PSI_RLU
 PS50889; S4 
PRINTS