CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023251
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FAS-associated factor 1 
Protein Synonyms/Alias
 hFAF1; UBX domain-containing protein 12; UBX domain-containing protein 3A 
Gene Name
 FAF1 
Gene Synonyms/Alias
 UBXD12; UBXN3A; CGI-03 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
139ELQIPVSKMLLKGWKubiquitination[1]
146KMLLKGWKTGDVEDSubiquitination[1]
157VEDSTVLKSLHLPKNubiquitination[1]
292AQTIRTQKTDQFPLFubiquitination[1]
305LFLIIMGKRSSNEVLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Potentiates but cannot initiate FAS-induced apoptosis. 
Sequence Annotation
 DOMAIN 1 57 UBA.
 DOMAIN 569 646 UBX.
 MOD_RES 270 270 Phosphoserine (By similarity).
 MOD_RES 320 320 Phosphoserine.
 MOD_RES 580 580 Phosphothreonine (By similarity).  
Keyword
 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 650 AA 
Protein Sequence
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSEYGGET 60
IPGPAFNPAS HPASAPTSSS SSAFRPVMPS RQIVERQPRM LDFRVEYRDR NVDVVLEDTC 120
TVGEIKQILE NELQIPVSKM LLKGWKTGDV EDSTVLKSLH LPKNNSLYVL TPDLPPPSSS 180
SHAGALQEFS SRYGDCHPVF FIGSLEAAFQ EAFYVKARDR KLLAIYLHHD ESVLTNVFCS 240
QMLCAESIVS YLSQNFITWA WDLTKDSNRA RFLTMCNRHF GSVVAQTIRT QKTDQFPLFL 300
IIMGKRSSNE VLNVIQGNTT VDELMMRLMA AMEIFTAQQQ EDIKDEDERE ARENVKREQD 360
EAYRLSLEAD RAKREAHERE MAEQFRLEQI RKEQEEEREA IRLSLEQALP PEPKEENAEP 420
VSKLRIRTPS GEFLERRFLA SNKLQIVFDF VASKGFPWDE YKLLSTFPRR DVTQLDPNKS 480
LLEVKLFPQE TLFLEAKE 498 
Gene Ontology
 GO:0031265; C:CD95 death-inducing signaling complex; NAS:UniProtKB.
 GO:0034098; C:Cdc48p-Npl4p-Ufd1p AAA ATPase complex; IDA:BHF-UCL.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005635; C:nuclear envelope; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0031072; F:heat shock protein binding; IDA:UniProtKB.
 GO:0019901; F:protein kinase binding; IDA:UniProtKB.
 GO:0019887; F:protein kinase regulator activity; NAS:UniProtKB.
 GO:0043130; F:ubiquitin binding; IDA:BHF-UCL.
 GO:0031625; F:ubiquitin protein ligase binding; IDA:BHF-UCL.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0008219; P:cell death; IMP:UniProtKB.
 GO:0007253; P:cytoplasmic sequestering of NF-kappaB; IMP:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; NAS:UniProtKB.
 GO:0031334; P:positive regulation of protein complex assembly; IMP:UniProtKB.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; NAS:UniProtKB.
 GO:0030155; P:regulation of cell adhesion; IEA:Compara.
 GO:0042176; P:regulation of protein catabolic process; IMP:UniProtKB. 
Interpro
 IPR006577; UAS.
 IPR001012; UBX. 
Pfam
 PF00789; UBX 
SMART
 SM00594; UAS
 SM00166; UBX 
PROSITE
 PS50030; UBA
 PS50033; UBX 
PRINTS