UniProt Accession

 RPA49_HUMAN; Q9GZS1; Q5VZT3; Q8NBA9; Q96L20 

Genbank Protein ID

 AK023452; AK024032; AK091294; CR457313; AL158156; AL158156; BC001337; BC014331 

Genbank Nucleotide ID

 BAB14579.1; BAB14791.1; BAC03629.1; CAG33594.1; CAH73518.1; CAH73519.1; AAH01337.1; AAH14331.1 

Protein Name

 DNA-directed RNA polymerase I subunit RPA49 

Protein Synonyms/Alias

 RNA polymerase I subunit A49; DNA-directed RNA polymerase I subunit E; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53 

Gene Name

 POLR1E 

Gene Synonyms/Alias

 PAF53; PRAF1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	LVQFSNGKLQSPGNM	ubiquitination	[1]
47	RFTLYENKDSTNPRK	ubiquitination	[2]
80	NFGTGALKCNTLCRH	ubiquitination	[2]
134	QTKTYREKMDSCIEA	ubiquitination	[2]
148	AFGTTKQKRALNTRR	ubiquitination	[2]
170	SLNRAVAKAAETIID	ubiquitination	[2]
309	VPHIINTKLLKHFTC	ubiquitination	[2]
312	IINTKLLKHFTCLTY	ubiquitination	[2]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity). 

Sequence Annotation

 MOD_RES 97 97 Phosphoserine.
 MOD_RES 225 225 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 481 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; ISS:HGNC.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0009303; P:rRNA transcription; ISS:HGNC. 

Interpro

 IPR009668; RNA_pol-assoc_fac_A49-like. 

Pfam

 PF06870; RNA_pol_I_A49 

SMART

  

PROSITE

  

PRINTS