UniProt Accession

 STEA3_HUMAN; Q658P3; A8K6E3; Q4VBR2; Q4ZG36; Q53SQ8; Q7Z389; Q86SF6; Q8NEW6; Q8TDP3; Q8TF03; Q9NVB5 

Genbank Protein ID

 AY214461; AF423424; AF238864; AF262322; AY029585; AY082673; AK001691; AK291608; AL833624; BX538047; AC016673; AC016736; CH471103; BC042150; BC095421 

Genbank Nucleotide ID

 AAO38238.1; AAQ04065.1; AAL78206.1; AAM08128.1; AAK50538.1; AAM45136.1; BAA91839.1; BAF84297.1; CAH56204.1; CAD97986.1; AAX88963.1; AAY14872.1; EAW95209.1; AAH42150.1; AAH95421.2 

Protein Name

 Metalloreductase STEAP3 

Protein Synonyms/Alias

 Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde 

Gene Name

 STEAP3 

Gene Synonyms/Alias

 TSAP6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
17	KMPEEMDKPLISLHL	ubiquitination	[1]
33	DSDSSLAKVPDEAPK	ubiquitination	[2]
349	DLVNLAVKQVLANKS	ubiquitination	[3]
482	WERESTIKFTLPTDH	ubiquitination	[1, 2, 3]
494	TDHALAEKTSHV***	ubiquitination	[1, 2, 3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. 

Sequence Annotation

 DOMAIN 259 407 Ferric oxidoreductase.
 METAL 316 316 Iron (heme axial ligand) (Probable).
 METAL 409 409 Iron (heme axial ligand) (Probable).
 BINDING 36 36 NADP.
 BINDING 38 38 NADP; via amide nitrogen.
 BINDING 39 39 NADP; via amide nitrogen.
 BINDING 58 58 NADP.
 BINDING 59 59 NADP.
 BINDING 91 91 NADP; via carbonyl oxygen.
 BINDING 116 116 NADP; via amide nitrogen.
 BINDING 151 151 NADP; via amide nitrogen.
 MOD_RES 17 17 Phosphoserine (By similarity).
 MOD_RES 20 20 Phosphoserine (By similarity).
 CARBOHYD 256 256 N-linked (GlcNAc...) (Probable).
 CARBOHYD 344 344 N-linked (GlcNAc...) (Probable).  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Cell cycle; Complete proteome; Copper; Endosome; FAD; Flavoprotein; Glycoprotein; Ion transport; Iron; Iron transport; Membrane; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 488 AA 

Protein Sequence

Gene Ontology

 GO:0010008; C:endosome membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005771; C:multivesicular body; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0000293; F:ferric-chelate reductase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0009306; P:protein secretion; IMP:UniProtKB.
 GO:0033572; P:transferrin transport; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 

Interpro

 IPR013130; Fe3_Rdtase_TM_dom.
 IPR016040; NAD(P)-bd_dom.
 IPR004455; NADP_OxRdtase_F420. 

Pfam

 PF03807; F420_oxidored
 PF01794; Ferric_reduct 

SMART

  

PROSITE

  

PRINTS