UniProt Accession

 CP3AB_MOUSE; Q64459 

Genbank Protein ID

 X60452; BC010528 

Genbank Nucleotide ID

 CAA42981.1; AAH10528.1 

Protein Name

 Cytochrome P450 3A11 

Protein Synonyms/Alias

 CYPIIIA11; Cytochrome P-450IIIAM1; Cytochrome P-450UT 

Gene Name

 Cyp3a11 

Gene Synonyms/Alias

 Cyp3a-11 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
29	LYRYGTRKHELFKKQ	acetylation	[1]
42	KQGIPGPKPLPFLGT	ubiquitination	[2]
59	NYYKGLWKFDMECYK	ubiquitination	[2]
66	KFDMECYKKYGKTWG	acetylation	[3]
66	KFDMECYKKYGKTWG	ubiquitination	[2]
70	ECYKKYGKTWGLFDG	ubiquitination	[2]
91	VTDPETIKNVLVKEC	ubiquitination	[2]
96	TIKNVLVKECFSVFT	ubiquitination	[2]
116	GPVGIMSKAISISKD	ubiquitination	[2]
122	SKAISISKDDEWKRY	ubiquitination	[2]
127	ISKDDEWKRYRALLS	acetylation	[4]
127	ISKDDEWKRYRALLS	ubiquitination	[2]
141	SPTFTSGKLKEMFPV	acetylation	[3]
141	SPTFTSGKLKEMFPV	ubiquitination	[2]
143	TFTSGKLKEMFPVIE	acetylation	[3]
143	TFTSGKLKEMFPVIE	ubiquitination	[2]
158	QYGDILVKYLRQKAK	ubiquitination	[2]
250	KDSIEFFKKFVDRMK	acetylation	[3]
250	KDSIEFFKKFVDRMK	ubiquitination	[2]
251	DSIEFFKKFVDRMKE	ubiquitination	[2]
266	SRLDSKQKHRVDFLQ	ubiquitination	[2]
283	MNSHNNSKDKVSHKA	ubiquitination	[2]
331	THPDIQKKLQDEIDE	ubiquitination	[2]
379	NRLERVCKKDVELNG	ubiquitination	[2]
380	RLERVCKKDVELNGV	ubiquitination	[2]
391	LNGVYIPKGSTVMIP	ubiquitination	[2]
422	FQPERFSKENKGSID	ubiquitination	[2]
425	ERFSKENKGSIDPYV	ubiquitination	[2]
454	RFALMNMKLALTKIM	ubiquitination	[2]
459	NMKLALTKIMQNFSF	ubiquitination	[2]
470	NFSFQPCKETQIPLK	ubiquitination	[2]
477	KETQIPLKLSRQGLL	ubiquitination	[2]
488	QGLLQPEKPIVLKVV	acetylation	[3, 4]
488	QGLLQPEKPIVLKVV	ubiquitination	[2]
493	PEKPIVLKVVPRDAV	acetylation	[3, 4]
493	PEKPIVLKVVPRDAV	ubiquitination	[2]

Reference

 [1] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation. 

Sequence Annotation

 METAL 443 443 Iron (heme axial ligand) (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 504 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IDA:MGI. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR008072; Cyt_P450_E_CYP3A.
 IPR002402; Cyt_P450_E_grp-II. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00464; EP450II.
 PR01689; EP450IICYP3A.
 PR00385; P450.