CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021026
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative gamma-secretase subunit APH-1C 
Protein Synonyms/Alias
  
Gene Name
 Aph1c 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
102KKASEGLKSINPEEDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein) (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Notch signaling pathway; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MTLPVFFGCA FIAFGPAFAL YLFTIATDPL RVIFLIAGAF FWLVSLLLSS MFWFLVRVIT 60
NNRDESVQNY LLIFGALLSV CIQELFRLAY YKLLKKASEG LKSINPEEDI APSMRLLAYV 120
SGLGFGIMSG VFSFVNTLSN SLGPGTVGIH GDSPQFFLNS AFMTLVVIML HVFWGVVFFD 180
GCEKNKWYTL LTVLLTHLVV STQTFLSPYY EVNLVTAYII MVLMGIWAFY VAGGSCRSLK 240
FCLLCQDKDF LLYNQRSR 258 
Gene Ontology
 GO:0016021; C:integral to membrane; ISA:MGI.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0004175; F:endopeptidase activity; IGI:MGI.
 GO:0001656; P:metanephros development; IMP:MGI.
 GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
 GO:0043085; P:positive regulation of catalytic activity; IEA:InterPro.
 GO:0016485; P:protein processing; IGI:MGI. 
Interpro
 IPR009294; Aph-1. 
Pfam
 PF06105; Aph-1 
SMART
  
PROSITE
  
PRINTS