CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025920
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Claudin 18 
Protein Synonyms/Alias
 Protein Cldn18; Similar to claudin-18A1.2, isoform CRA_b 
Gene Name
 Cldn18 
Gene Synonyms/Alias
 LOC315953; rCG_25983 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
221SGQNVAYKPGGFKASacetylation[1]
239GSNARNKKIYDGGARacetylation[1]
257DEQSHPTKYDYV***acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Complete proteome; Membrane; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MATTTCQVVG LLLSLLGLAG CIAATGMDMW STQDLYDNPV TSVFQYEGLW RSCVQQSSGF 60
TECRPYFTIL GLPAMLQAVR ALMIVGIVLG VIGILVSIFA LKCIRIGSMD DSAKAKMTLT 120
SGIMFIISGV CAIIGVSVFA NMLVTNFWMS TANMYSGMGG MVQTVQTRYT FGAALFVGWI 180
AGGLTLIGGV MMCIACRGLT PDDRNFKAVS YHASGQNVAY KPGGFKASTG FGSNARNKKI 240
YDGGARTEDD EQSHPTKYDY V 261 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0005923; C:tight junction; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 
Interpro
 IPR006187; Claudin.
 IPR003928; Claudin18.
 IPR017974; Claudin_CS.
 IPR004031; PMP22/EMP/MP20/Claudin. 
Pfam
 PF00822; PMP22_Claudin 
SMART
  
PROSITE
 PS01346; CLAUDIN 
PRINTS
 PR01077; CLAUDIN.
 PR01448; CLAUDIN18.