UniProt Accession

 CLIC5_RAT; Q9EPT8 

Genbank Protein ID

 AF323174 

Genbank Nucleotide ID

 AAG49367.1 

Protein Name

 Chloride intracellular channel protein 5 

Protein Synonyms/Alias

  

Gene Name

 Clic5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
59	TTVDLKRKPADLHNL	acetylation	[1]
87	DVKTDVNKIEEFLEE	acetylation	[1]
100	EETLTPEKYPKLAAR	acetylation	[1]
103	LTPEKYPKLAARHRE	acetylation	[1]
147	GLTKALRKLDDYLNT	acetylation	[1]
169	TNTHGDEKGSQRKFL	acetylation	[1]
196	LPKLHVVKIVAKKYR	acetylation	[1]
196	LPKLHVVKIVAKKYR	ubiquitination	[2]
219	TGLWRYLKNAYARDE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Required for normal formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). 

Sequence Annotation

 DOMAIN 101 241 GST C-terminal.
 REGION 1 98 Required for insertion into the membrane  

Keyword

 Chloride; Chloride channel; Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 251 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0032420; C:stereocilium; IEA:Compara.
 GO:0032421; C:stereocilium bundle; IDA:MGI.
 GO:0005254; F:chloride channel activity; IDA:RGD.
 GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
 GO:0060088; P:auditory receptor cell stereocilium organization; IEA:Compara.
 GO:0002024; P:diet induced thermogenesis; IEA:Compara.
 GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR002946; Int_Cl_channel.
 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

 PS50405; GST_CTER 

PRINTS

 PR01263; INTCLCHANNEL.