UniProt Accession

 SKA2_MOUSE; Q9CR46; B2KGY1 

Genbank Protein ID

 AK003196; AK013317; AK013370; AK017811; AK162628; AL713917; CU468043; CH466556; BC117001; BC119167 

Genbank Nucleotide ID

 BAB22634.1; BAB28787.1; BAB28814.1; BAB30948.1; BAE36998.1; CAI25315.1; CAQ51630.1; EDL15809.1; AAI17002.1; AAI19168.1 

Protein Name

 Spindle and kinetochore-associated protein 2 

Protein Synonyms/Alias

 Protein FAM33A 

Gene Name

 Ska2 

Gene Synonyms/Alias

 Fam33a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
65	QALCARFKAVSVEQK	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization (By similarity). 

Sequence Annotation

  

Keyword

 Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 120 AA 

Protein Sequence

Gene Ontology

 GO:0000940; C:condensed chromosome outer kinetochore; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005876; C:spindle microtubule; ISS:UniProtKB.
 GO:0008017; F:microtubule binding; ISS:UniProtKB.
 GO:0051301; P:cell division; ISS:UniProtKB.
 GO:0007059; P:chromosome segregation; ISS:UniProtKB.
 GO:0000090; P:mitotic anaphase; ISS:UniProtKB.
 GO:0031110; P:regulation of microtubule polymerization or depolymerization; ISS:UniProtKB. 

Interpro

 IPR026762; Ska2. 

Pfam

  

SMART

  

PROSITE

  

PRINTS