CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037019
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Presenilin-1 
Protein Synonyms/Alias
  
Gene Name
 PSEN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17SVSFYTRKDGQLIYTubiquitination[1, 2]
222RRVSKNSKYNAESTEubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MVVVVATIKS VSFYTRKDGQ LIYTPFTEDT ETVGQRALHS ILNAAIMISV IVVMTILLVV 60
LYKYRCYKVI HAWLIISSLL LLFFFSFIYL GEVFKTYNVA VDYITVALLI WNFGVVGMIS 120
IHWKGPLRLQ QAYLIMISAL MALVFIKYLP EWTAWLILAV ISVYDLVAVL CPKGPLRMLV 180
ETAQERNETL FPALIYSSTM VWLVNMAEGD PEAQRRVSKN SKYNAESTER ESQDTVAEND 240
DGGFSEEWEA QRDSHLGPHR STPESRAAVQ ELSSSILAGE DPEERGVKLG LGDFIFYSVL 300
VGKASATASG DWNTTIACFV AILIGLCLTL LLLAIFKKAL PALPISITFG LVFYFATDYL 360
VQPFMDQLAF HQFYI 375 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0035253; C:ciliary rootlet; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0043198; C:dendritic shaft; IEA:Compara.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
 GO:0000186; P:activation of MAPKK activity; IEA:Compara.
 GO:0042987; P:amyloid precursor protein catabolic process; IEA:Compara.
 GO:0042640; P:anagen; IEA:Compara.
 GO:0000045; P:autophagic vacuole assembly; IEA:Compara.
 GO:0050435; P:beta-amyloid metabolic process; IEA:Compara.
 GO:0001568; P:blood vessel development; IEA:Compara.
 GO:0048854; P:brain morphogenesis; IEA:Compara.
 GO:0021870; P:Cajal-Retzius cell differentiation; IEA:Compara.
 GO:0001708; P:cell fate specification; IEA:Compara.
 GO:0021795; P:cerebral cortex cell migration; IEA:Compara.
 GO:0015871; P:choline transport; IEA:Compara.
 GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Compara.
 GO:0030326; P:embryonic limb morphogenesis; IEA:Compara.
 GO:0050673; P:epithelial cell proliferation; IEA:Compara.
 GO:0001947; P:heart looping; IEA:Compara.
 GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0015813; P:L-glutamate transport; IEA:Compara.
 GO:0007613; P:memory; IEA:Compara.
 GO:0006839; P:mitochondrial transport; IEA:Compara.
 GO:0002573; P:myeloid leukocyte differentiation; IEA:Compara.
 GO:0050771; P:negative regulation of axonogenesis; IEA:Compara.
 GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0051444; P:negative regulation of ubiquitin-protein ligase activity; IEA:Compara.
 GO:0051402; P:neuron apoptotic process; IEA:Compara.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0007220; P:Notch receptor processing; IEA:Compara.
 GO:0007219; P:Notch signaling pathway; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0050820; P:positive regulation of coagulation; IEA:Compara.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0001921; P:positive regulation of receptor recycling; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0006486; P:protein glycosylation; IEA:Compara.
 GO:0051604; P:protein maturation; IEA:Compara.
 GO:0015031; P:protein transport; IEA:Compara.
 GO:0043393; P:regulation of protein binding; IEA:Compara.
 GO:0060075; P:regulation of resting membrane potential; IEA:Compara.
 GO:0048167; P:regulation of synaptic plasticity; IEA:Compara.
 GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Compara.
 GO:0006974; P:response to DNA damage stimulus; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0048705; P:skeletal system morphogenesis; IEA:Compara.
 GO:0043589; P:skin morphogenesis; IEA:Compara.
 GO:0051563; P:smooth endoplasmic reticulum calcium ion homeostasis; IEA:Compara.
 GO:0001756; P:somitogenesis; IEA:Compara.
 GO:0016080; P:synaptic vesicle targeting; IEA:Compara.
 GO:0002286; P:T cell activation involved in immune response; IEA:Compara.
 GO:0050852; P:T cell receptor signaling pathway; IEA:Compara.
 GO:0048538; P:thymus development; IEA:Compara. 
Interpro
 IPR002031; Pept_A22A_PS1.
 IPR006639; Peptidase_A22.
 IPR001108; Peptidase_A22A. 
Pfam
 PF01080; Presenilin 
SMART
 SM00730; PSN 
PROSITE
  
PRINTS
 PR01072; PRESENILIN.