CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024325
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Obscurin 
Protein Synonyms/Alias
 Obscurin-RhoGEF; Obscurin-myosin light chain kinase; Obscurin-MLCK 
Gene Name
 Obscn 
Gene Synonyms/Alias
 Gm878 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
705ALGLPSSKLPAAAARubiquitination[1]
927LVVQQAGKADAGEYSubiquitination[1]
3129DKYDFLHKAGARGLTubiquitination[1]
6153SMGVSSTKAELRVELubiquitination[1]
6346APSVHWLKEEAEKGVacetylation[2]
8341LGLRQRVKASMAHISubiquitination[1]
8352AHISRILKGRPEGPEubiquitination[1]
8367REGPPRKKAGLASFRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 
Functional Description
 Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle (By similarity). 
Sequence Annotation
 DOMAIN 9 99 Ig-like 1.
 DOMAIN 109 201 Ig-like 2.
 DOMAIN 234 320 Ig-like 3.
 DOMAIN 329 415 Ig-like 4.
 DOMAIN 510 605 Fibronectin type-III 1.
 DOMAIN 702 793 Ig-like 5.
 DOMAIN 859 951 Ig-like 6.
 DOMAIN 951 1043 Ig-like 7.
 DOMAIN 1043 1135 Ig-like 8.
 DOMAIN 1135 1227 Ig-like 9.
 DOMAIN 1227 1319 Ig-like 10.
 DOMAIN 1319 1407 Ig-like 11.
 DOMAIN 1411 1503 Ig-like 12.
 DOMAIN 1503 1595 Ig-like 13.
 DOMAIN 1595 1687 Ig-like 14.
 DOMAIN 1687 1779 Ig-like 15.
 DOMAIN 1779 1871 Ig-like 16.
 DOMAIN 1871 1963 Ig-like 17.
 DOMAIN 1963 2051 Ig-like 18.
 DOMAIN 2055 2147 Ig-like 19.
 DOMAIN 2152 2241 Ig-like 20.
 DOMAIN 2242 2325 Ig-like 21.
 DOMAIN 2329 2415 Ig-like 22.
 DOMAIN 2420 2504 Ig-like 23.
 DOMAIN 2598 2681 Ig-like 24.
 DOMAIN 2721 2812 Ig-like 25.
 DOMAIN 2900 2984 Ig-like 26.
 DOMAIN 3078 3162 Ig-like 27.
 DOMAIN 3258 3342 Ig-like 28.
 DOMAIN 3348 3431 Ig-like 29.
 DOMAIN 3527 3610 Ig-like 30.
 DOMAIN 3616 3700 Ig-like 31.
 DOMAIN 3785 3876 Ig-like 32.
 DOMAIN 3881 3964 Ig-like 33.
 DOMAIN 4041 4124 Ig-like 34.
 DOMAIN 4129 4212 Ig-like 35.
 DOMAIN 4218 4300 Ig-like 36.
 DOMAIN 4306 4388 Ig-like 37.
 DOMAIN 4394 4476 Ig-like 38.
 DOMAIN 4482 4564 Ig-like 39.
 DOMAIN 4570 4652 Ig-like 40.
 DOMAIN 4658 4740 Ig-like 41.
 DOMAIN 4745 4828 Ig-like 42.
 DOMAIN 4832 4915 Ig-like 43.
 DOMAIN 4922 5006 Ig-like 44.
 DOMAIN 5012 5104 Ig-like 45.
 DOMAIN 5374 5460 Ig-like 46.
 DOMAIN 5465 5556 Fibronectin type-III 2.
 DOMAIN 5553 5650 Ig-like 47.
 DOMAIN 5812 5841 IQ.
 DOMAIN 5838 5921 Ig-like 48.
 DOMAIN 6068 6157 Ig-like 49.
 DOMAIN 6200 6289 Ig-like 50.
 DOMAIN 6311 6407 Ig-like 51.
 DOMAIN 6540 6607 SH3.
 DOMAIN 6633 6817 DH.
 DOMAIN 6835 6944 PH.
 DOMAIN 6954 7037 Ig-like 52.
 DOMAIN 7048 7138 Ig-like 53.
 DOMAIN 7305 7393 Ig-like 54.
 DOMAIN 7415 7668 Protein kinase 1.
 DOMAIN 8385 8469 Ig-like 55.
 DOMAIN 8479 8566 Fibronectin type-III 3.
 DOMAIN 8595 8847 Protein kinase 2.
 NP_BIND 7421 7429 ATP (By similarity).
 NP_BIND 8601 8609 ATP (By similarity).
 ACT_SITE 7534 7534 Proton acceptor (By similarity).
 ACT_SITE 8714 8714 Proton acceptor (By similarity).
 BINDING 7444 7444 ATP (By similarity).
 BINDING 8624 8624 ATP (By similarity).
 DISULFID 30 81 By similarity.
 DISULFID 257 309 By similarity.
 DISULFID 352 402 By similarity.
 DISULFID 885 935 By similarity.
 DISULFID 977 1027 By similarity.
 DISULFID 1069 1119 By similarity.
 DISULFID 1161 1211 By similarity.
 DISULFID 1253 1303 By similarity.
 DISULFID 1345 1395 By similarity.
 DISULFID 1437 1487 By similarity.
 DISULFID 1529 1579 By similarity.
 DISULFID 1621 1671 By similarity.
 DISULFID 1713 1763 By similarity.
 DISULFID 1805 1855 By similarity.
 DISULFID 1897 1947 By similarity.
 DISULFID 1989 2039 By similarity.
 DISULFID 2081 2131 By similarity.
 DISULFID 2263 2313 By similarity.
 DISULFID 2620 2669 By similarity.
 DISULFID 2743 2793 By similarity.
 DISULFID 2922 2972 By similarity.
 DISULFID 3100 3150 By similarity.
 DISULFID 3280 3330 By similarity.
 DISULFID 3369 3419 By similarity.
 DISULFID 3549 3599 By similarity.
 DISULFID 3638 3688 By similarity.
 DISULFID 3815 3864 By similarity.
 DISULFID 3903 3952 By similarity.
 DISULFID 4063 4112 By similarity.
 DISULFID 4151 4200 By similarity.
 DISULFID 4239 4288 By similarity.
 DISULFID 4327 4376 By similarity.
 DISULFID 4415 4464 By similarity.
 DISULFID 4503 4552 By similarity.
 DISULFID 4591 4640 By similarity.
 DISULFID 4679 4728 By similarity.
 DISULFID 4767 4816 By similarity.
 DISULFID 4855 4905 By similarity.
 DISULFID 4944 4994 By similarity.
 DISULFID 5033 5085 By similarity.
 DISULFID 5581 5634 By similarity.
 DISULFID 5859 5911 By similarity.
 DISULFID 6089 6141 By similarity.
 DISULFID 6975 7027 By similarity.
 DISULFID 7069 7122 By similarity.
 DISULFID 8406 8458 By similarity.  
Keyword
 Alternative splicing; ATP-binding; Calmodulin-binding; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Immunoglobulin domain; Kinase; Muscle protein; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; SH3 domain; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 8891 AA 
Protein Sequence
MDHSFSGAPR FLTRPKAFVV SVGKDATLSC QIVGNPTPHV SWEKDRQPVE AGARFRLAQD 60
GDVYRLTILD LALGDSGQYV CRARNAIGEA FAAVGLRVDS EGTCAEQAPH FLLRPTSIRV 120
REGADATFRC RVGGSPQPAV SWSKDGRRLG PPDAPHVRVE EHGESSALRI RSARPRDGGT 180
YEVRAENPLG SASAAAALVV DSDAEVAGPP GTSTATLLAH LQQRREAMRA EGIPPSPPGA 240
GTRTCTVTEG KHARLSCFVT GEPKPETVWK KDGQLVTEGR RHVVYEDEQE NFVLKILFCK 300
QSDRGLYTCT ASNLVGQTYS SVLVVVREPT VPFKKRLQDL EVREKESATF QCEVAQPATE 360
AAWFKEETRL WASAKYDIEE EGTERRLTVR NVSADDDAVY ICETTEGSRT VAELSVQGNL 420
TRKLPRKTAV RTGDTAIFWV ELAVPEGPVR WLRNQEEMVA GGRVAITAEG TCHTLTIFQC 480
TLEDMGEVAF VSGGCRTTTQ FCVSAPRRPP LYPPADPVVK AKTESSVTLS WSAPPHGDRP 540
VTIDGYVLEK RKLGAYAWSR CHEAGWLATT EFTITGVAEE GDFQFRVSAI NHFGQGPYLE 600
FPGTMHLVPM LAVKTPLKAV EAVEGGEVTF SVDLTVASSG EWFLDGEALK ASSIYVIRCD 660
RTRHMLTIRE VPARLHGAQL KFVANGIETS IQMVVRAALG LPSSKLPAAA AREVLAQLHE 720
EAQLLAELSD QAAAVTWLKD GRELSLGPKY EMQVSAGRRA LLVRDVAQDD AGLYECVSRG 780
SRTAYQLLVQ DITDGYRDWG PAGPQKHMCK CAGAKIARYL GSSCYRFLQY DKGVWHWLEA 840
ALDTRQGKGT SSCSLHEKPK LVFAKGQQAH SEVKAEAGNS ATLSCEVTQA QTEVTWFKDG 900
KKLSSSSKVR MEASGCSRRL VVQQAGKADA GEYSCEAGGQ KLSFRLDVAE PKLVFAKGQQ 960
AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK VRMEASGCSR RLVVQQAGKA 1020
DAGEYSCEAG GQKLSFRLDV AEPKMVFAKE QQARSEVKAE AGASATLSCE VAQAQTEVTW 1080
FKDGKKLSSS SKVRMEASGC SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVTEPKLVFA 1140
KEQQARSEVK AEVGNSATLS CEVAQAQTEV TWFKDGKKLS SSSKVRMEAS GCSRRLVVQQ 1200
AGKADAGEYS CEAGGQKLSF RLDVAEPKLV FAKEQQARSE VKAEAGNSAT LSCEVAQAQT 1260
EVTWFKDGKK LSSSSKVRME ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFHLDVTEPK 1320
LVFAKEQQAH SEVKAEAGAS ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR MEASGCSRRL 1380
VVQQAGKADA GEYSCEAEGQ KLSFRLDVAE PKLVFAKEQQ ARSEVKAEAG ASATLSCEVA 1440
QAQTEVTWFK DGKKLSSSSK VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV 1500
AEPKLVFAKE QQANSEVKAE AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC 1560
SRRLVVQQAG KADAGEYSCE AGGQKLSFRL DVAEPKLAFA KEQQAHSEVK AEAGASATLS 1620
CEVAQAQTEV TWFKDGKKLS SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF 1680
RLDVAEPKLA FAKEQQAHSE VKAEAGASAT LSCEVAQAQT EVTWFKDGKK LSSSSKVRVE 1740
ASGCSRRLVV QQAGKADAGE YSCEAGGQKL SFRLDVAEPK LAFAKEQQAH SEVKAEAGAS 1800
ATLSCEVAQA QTEVTWFKDG KKLSSSSKVR VEASGCSRRL VVQQAGKADA GEYSCEAGGQ 1860
KLFFRLDVAE PKLMFAKEQQ AHSEVKAEAG ASATLSCEVA QAQTEVTWFK DGKKLSSSSK 1920
VRVEASGCSR RLVVQQAGKA DAGEYSCEAG GQKLSFRLDV AEPKLVFAKE QQAHSEVKAE 1980
AGASATLSCE VAQAQTEVTW FKDGKKLSSS SKVRVEASGC SRRLVVQQVG KADAGEYSCE 2040
ARGQKLSFRL DVADTRLMFA KEQQARTEVK AEAGNSATLS CEVAQAQTEV TWFKDGKKLS 2100
SSSKVRVEAS GCSRRLVVQQ AGKADAGEYS CEAGGQKLSF RLDVAEAESQ IPERPSRREP 2160
LVVKEHETII LTATIAAPSV AAVTWLKDGV EIRRSKRHEA TSLGDTHTLT VRGAQVLDSA 2220
IYSCRVGKEG QDFPVQVEEV AAKFSKPLEP VEGELGGTVM LVCELSPEQA EVVWRCGNTQ 2280
LRPGKRFQMT SEGPRRTLTV SGLREDDAEE YVCESRDDRT SARLTVKVPR VVKFTSGLSA 2340
MVAEEGQEAT FQCVVSPSDA GVTWYKDGMQ LQPSEKFVMV ESGASRSLTI LGLTLEDAGQ 2400
VTVEAEGASS SAALRVREAP VLFKKKLEPQ TVEERTSVTL EVELTRPWPE VKWTRNAAVL 2460
TPSENVEIRA EGARHCLVLR SVGFADRGFF GCETPDDKTQ AKLNVEMRQV RLVRGLQEVE 2520
AKEQGTASMD VELSHAEVEG SWTRDGLRLQ PGPKCHLAVQ GPVHILTLSA LQPQDSGLVA 2580
FRAEGVHTSA RLIVTELPVS FTRVLQDVVA TQKEKVTLEC ELSRPVDVRW LKDGVELRAG 2640
KAIGIVAQGT CRSLVIYRCE TGDQGVYVCD ALDAQTSASL RVQGRTYTLI FRRVLAEDAG 2700
EVKFVAENAE SRAHLRVKEL PVTLLRPLRD KIAMEKHRGV LECQVSRASA QVRWFKGGVE 2760
LQSGPKYEVV SDGLYRKLVI NDVQPEDEDT YTCDAGNVKT SAQFFVEEQS ITIVRGLKDM 2820
TVMEPAPAWF ECETSIPSVR PPKWLLGKTV LQAGGNVGLE QDGTVHRLTL HKTCSTMTGP 2880
VHFTIGKSRS SAQLVVSDIP VVLTRPLEPK AGRELQSVVL SCDFRPAPKA VQWYKDDTPL 2940
SPSEKFKMAL EGQMAELRIL RLTPADAGVY RCQAGSAQSS AEVTVEAREV TVIQPLQDAE 3000
AMEEGRVCFS CELSHKDEDI EWSLNGTPLY NDSFHEISHE GCLHTLVLKS VRQADTGTVC 3060
ATSPKVSVSA RLVVKGKPVV FLKALDDVSA EERGTLTLQC EVSDPEARVV WRKDGVELGP 3120
SDKYDFLHKA GARGLTVHDL SHEDAGLYTC QVGSKETQSK VSVHDLHVGI TKRLKTVEVL 3180
EGESCSFECV LSHESPSDPA VWTVGGKTVG GSGHFHAVRQ GRKYTLTVKD AALSDAGEVV 3240
FSVLGLTSKA SLIIRERPVD ITKPLEDQRT TLGEDVMLSC ELSRAGTSVR WLKDGKAIRK 3300
SQKYDLLSEG TRAVLVVRKA SLKDSGEYTC ETEASKSTAK LCVEEKANRF TEELADLQVE 3360
EKGRAVFTCK TEHPASVVTW RKGLLELRAS GKHVPSQEGL TLKLTINALE RTDSDTYTCD 3420
IGQARTQARL LVHGQKVRVI EDLEDTAVQE GSSAKFCCRI APADYGPVHW FLDKTPLHSN 3480
ELNEITVQPG GYHVLTLRQL ALKDSGTVYF EAGDQRTSAA LRVTEKPSIF SRPLTDVTVT 3540
EGEDLTLVCE TTTVDSSVRW TKDGKTLRPS ARCQLSHEGC QAQLLITATT PQDGGRYKCE 3600
IGGASSSSIV RVHALPVRFR ESLKDVEVPE GKAATLRCVL SSVAAPVEWR HGDDVLKSSN 3660
KYSLRQEGAV LELVIRDLQP QDSGQYSCSF GDQTTSATLT VKTSSAQFVG KLRNKEATEG 3720
TTVTLRCELT KEAPVEWKKG TETLRNGDKY SLKQDGAVCE LQICSLLVAD AGEYSCVCGQ 3780
EKTSATLTVK ALLVHFVRRL RSKEATEGDT TTLQCELSKA APVEWRKGTE TLRDGDRYSL 3840
KQDGAVCELQ IRSLTIADAG EYLCTCGQEK TSATLTVRAL PAKFKDSLKN EEATEGTTAT 3900
LSCELSKAAP VTWKKGPKTL QSGDKYVLRQ DGAVCGLQIH GLTMADAGEY SCVCGQEKTS 3960
ATLTVRGLPA KFIEDLRSQE ATEGATAILR CELSKAAPVE WRKGSETLKD GDRYTLRQDG 4020
AVCELQIRGL AVVDTGTYSL PTKFTEGLRN EEATEGTMAT LRCQMSKAAP VEWRKGSETL 4080
RDGDRYSLRQ DGAMCELQIR GLTIEDSGEY TCVCGQEKTS ATLSVKALPS RFIEDLRSQE 4140
ATEGTMATLR CQMSKTAPVE WKKGSETLRD GGRYSLRQDG PVCELQICDL AVEDAGEYSC 4200
VCGQEKTSAT LSIKALPPRF IEDLRSQEAT EGTMATLRCQ MSKAAPVEWR KGSETLGDGG 4260
RYSLRQNGAV CELQIHDLAV EDTGEYSCVC GQEKTSATLN VKALPPRFIE DLRSQEATEG 4320
TMATLRCQMS KAAPVEWRKG SETLRDGGRY SLRQDGAVCE LQIHDLDVED AGQYSCVCGQ 4380
EKTSAVLTVD ALPPKFTEGL KKEEATEGTM VTLRCQMSKE ATVEWRKGAK TLSDGGRYSL 4440
RQDGAMCELQ ICGLAVEDAG EYSCVCGQEK TSATLSVKAL PPRFIEDLRS QEATEGTMAT 4500
LRCQMSKAAP VEWRKGSETL RDGDRYSLRQ DGAVCELQIR DLAVEDAGEY LCVCGQEKTS 4560
ATLSVKALPP RFIEDLRSQE ATEGTMATLR CQMSKAAPVE WRKGSKTLRD GDRYSLRQDG 4620
AMCELQICDL AVEDTGDYSC VCGQEKTSAT LSVKALPPRF IEDLRSQEAR EGTVATLRCR 4680
MSKAAPVEWR KGSETLKDGD RYSLRQEGNL CELQIRDLAV EDTEEYSCVC GQEKTSATLS 4740
VKALPAKFIE DLRSQEAPES STVTLRCKLS KKASVVWKKG SETLRNGARY SLRQDGAVCE 4800
LEIRDLTVED TGEYSCTCGQ ERTSATLSIM APQVVFQQPL QNLQAEEGSM ASLRCELSVP 4860
NAAMVWSKGG LELQGDTRRE ARQQGCVAEL LLRDLRREDA GEYSCTCGSQ TTSATLMVTA 4920
APVRFLRELQ AQDVDEGATA RLRCELSREA VSVEWRKGSL QLFPCAKYQM VQEGTTAELL 4980
VHGVEQEDAG EYTCDAGHTQ SIARLSVRAP KPKFKTDLQS TEQEAGGTAR LCCQLSEAEP 5040
GTPVQWLKEG VELHVGSKYE MRRQGAVCEL LIHGLEAKDT GEYACLVGGQ KTLASLRVKE 5100
PEVTIVRGLV DMEVQADEDV EFTCKVSQAG ATDVQWHLQG LPLQSNEVTE VAVLADGCTH 5160
VLQLKGVTLE DAGTVSFHVG GLSSSAQLTV RGDRSGAPEG CAAQRGPGCP LPVPTVQGLG 5220
PGGSLGFGRG SLAVQRDERH HCGAGHTLPA HSAQGDPGGC WDHHSPSGLM LLRGPAEGHS 5280
KNTVLRGLEN VDALEGGEAL FECQLSQPEV AAHTWLLDDE PVHTSEKVEV VYFENGLRHL 5340
LLLKNLKPQD SCRVTFLAGD VVTSAFLTVR GWRLEVLEPP HDASVKAGMQ VRFTCILSEA 5400
VPVGEATWYI NGAAIQPDDT DWTVTTDGSH HALTLSNAQP QHAGEVTFAA RDAVASARLS 5460
VLALPDPPED AEVVGRSDHS VTLSWVAPMS DGGGGLCGYR VEMKEASTGQ WQLCHDLVPG 5520
PECVVDDLVP GKTYRFRVAA VGPAGAGEPV HLPQMAPAPA PAPAPAPAPE TRQAVVGEDI 5580
CLELEVAADG GEVVWHKGTE RIQPGGHFEV LSRGQRQMLV IKGFRTEDQG EYRCGPIQGL 5640
PSSGAATFNV VMTSGSGDEV PAQPSLPPEA AQEGDLHLLW EALARKRRMS REPTLDSISE 5700
LPEEDSRVQH LRQEAEETAP DLSEGYSTAD ELARTGEADL SHTSSDDESR AGTPSLVTYL 5760
KKAGGPGISP LASKHEAQVT TSVKPQKQQE PVVPTCPPPG DLSAADLMDP SLDKAAVKIQ 5820
AAFKGYKVRK EMKQQEGPVF SRTFGDTEAQ VGDVLRLECV LATKTDMRAC WLKDGIELTD 5880
GRHYHIDQLK DGTCSLLVTG LAPTDSGRYT CQVSTKSGRV SHSACVVVSG TESEAESSSG 5940
GELDDAFRRA ARRLHRLFRT KSPAELSEEE LFLSADEGPG EPEEPADWQT YREDENFVCI 6000
RFESLAEARQ AVTCFRNMFA TMGIGVEISL GEQGPRGVEM RIGKVAPTVT PAVPLAKTPG 6060
LQTSDAAPVF LTELQNQDVQ DGYPMSFDCV VTGQPVPSVR WFKDGKLLEE DDHYMINEDQ 6120
QGGHQLIITA VVPADMGVYR CLAENSMGVS STKAELRVEL TSTDYDTAAD ATETSSYFSA 6180
QGYLSSREQE GTESDEGQLP QVLEELKDLQ VAPGTRLAKF QLKVKGYPAP KLYWFKDGQP 6240
LTTSDHIRMT DKKTLHTLEI VSVTREDSGQ YAAYISNAVG AAYSSARLLV RGPSEPEEKP 6300
ASDVHERLVP PRILEKFTPK KVKRGSSITF SVKVEGHPAP SVHWLKEEAE KGVLWIGPDT 6360
PGYTMASSSK QHSLVLLDVG RQHQGTYTCI ATNPAGQALC SASLHISGLA KEEEQERVKE 6420
ALISSFLQGT SQAVSAQMSE SAGFADLVGQ SKGESLVAEE AHSHLSLAEV GTEEFLQKLT 6480
SQITEMVSAK ISQAKLQVPG GDSDEETKTP SASPRHGRSR PSSSVQESSS ESEDGDSRGE 6540
IFDIYVVTAD YLPLGAEQDA IILREGQYVE VLDSAHPLRW LVRTKPTKSS PSRQGWVSPA 6600
YLDKRLKLSP EWGPTEAPEF PGEAVSEDEY RTRLSSVIQE LLSSEQAFVG ELQFLESHHM 6660
KHLERSPRVP AAVASQKTVI FRNVQDISHF HSSFLKELQG CGTDDDVAMC FIKNQEAFEK 6720
YLEFLVGRVQ AESVVVSTPV QEFYKKYAEE TLSAKDPTQP PPPPLQHYLE QPVERVQKYQ 6780
ALLKELIRNK ARNRQNCALL EQAYAVVSAL PQRAENKLHV SLMENYPGTL EALGEPIRQG 6840
HFIVWEGAPG ARMPWKGHNR HVFLFRNYLV ICKPRRDSRT DTFSYVFRNM MKLSSIDLND 6900
QVEGDDRAFE VWHEREDSVR KYLLQARTVI IKNSWVKEIC GIQQRLAQPV WRPPEFEEEL 6960
ADCTAELGET VKLACRVTGT PKPIVSWYKD GKPVEVDPHH ILIEDPDGSC TLILDNLTGI 7020
DSGQYMCFAA SAAGNASTLG KILVQVPPRF VNKVRATPFV EGEDAQITCT VEGAPYPQIR 7080
WYKDGTLLAP GNRYRMLNEP RSGVLVLVIQ AASKEDLGHY ECELVNRLGS TRGGGELYMQ 7140
SPALRARDQH HREQIVAAVE VCSHDTSVEG SAHSAQDGAD QQAASVLWRL LGSEALGPSP 7200
GDLPNTRQSE PPAFEEAASQ IPGAASGTPG ELPEVSQPGT HKGLEQETTS SGSQGWTVPI 7260
RVEGTAWPGA GTGQLLLDVH SQVIMETTQR TYVCQAPDTG VTRAPSMQVT IEDVQVQVGD 7320
MAQFDAVIEG HPPPIVTWYK GSTQLTSSAR LSQRQDGTTY SLVLTDVAPH DAGVYTCVAN 7380
NAGGQVLCKA ELLVHGGDKL DAENQVYRRK LHSFYDVQEE IGRGVFGFVK RVQHKGNKMF 7440
CAAKFIPLRS KTRAQAYQER DILATLGHPL VTGLLDQFET RKTLILILEL CSSEELLDRL 7500
FKKGVVTEAE VKVYIQQLVE GLHYLHSHGI LHLDIKPPNI LMVHPAREDI KICDFGFAQK 7560
ITPSEPQYSK YGSPEFVSPE IIEQNPVSEG SDIWAMGVIS YLSLTCSSPF AGESDRATLL 7620
NVLEGRVSWS SPTAAHLSED AKDFIKATLQ RTPRARPSTS QCLAHPWFLK SMPAEEAHFI 7680
NTKQLKFLLA RSRWQRSLMS YKSILVMRSI PELLQGPPDS PSLGVARHLR GEASGASSSS 7740
SSSDNELAPF ARAKSLPPSP VTHSPLLHPR GFLRPSASLP EETEASMPTA DAAVPASPQS 7800
AGPPASPGCV PRHSVISSLF YQQAGEGAER GNKTSGAKRH PARRRHLLKG GYIARALPGL 7860
REPLMEYSLL EEEAAREEQA SLMTKTPSFE TALRLPSSSV REVPGRSHSL DNPPVTTGPS 7920
PEACKEQLLF PPSTGLTHET TAKDRGHKEG FLQESVPFPP MSGDSRPGKQ EGSSQDSCRG 7980
KPASSCHSEL GSGSQEGCGP PSSQSLGSLP PQSLKKELST SCGPLFSEQP QAAPFPTQVS 8040
PLLGSEKEPQ DGSLSEGPVP VPSSSPGSAS QVDASLDTEG LSEAGDTCDF TPPPQRPQEQ 8100
ATTRKFSLES RGGYAGVAGY GTFAFGGDAG GMLGQGPLWA RMAWAVSQSS EEQDEAATES 8160
PQPLESLGPI AEASGVPLRT SPSLTPWEEV EQVSLVQIRD LSGDAEAADT ISLDISEVDP 8220
AYLNLSDLYD IKYLPFEFMI FRRVPKPIEQ PESPGSETEA GQGLADFLEE AAWPWPGELG 8280
LRAGLEITEE PEEPGDLEAL LGEAAVGRKR KWSPSRGLFQ FPGRCLSGEE PVELGLRQRV 8340
KASMAHISRI LKGRPEGPER EGPPRKKAGL ASFRLSGLKG RDQAPSFLRE LSDEAVVLGQ 8400
SVTLACQVLA QPTAQATWSK DGVLLESSGH LLISSTLKNF QLLTILVVKE EDLGTYTCCV 8460
SNPLGTAVTT GVLRKAERPS SSPRPEVGEL YKDAVLLVWK PVESCGPVTY IVQCCIEGGS 8520
WTTLASDISD CCYLTGKLSR GGMYIFRTAC VSKAGMGPYS SPSEQVLLGG PNHLASEEES 8580
SRGRPAQLLP STKTFAFQMQ IRRGRFSVVR QCREKASGRA LAAKIVPYQP EDKTAVLREY 8640
EALKRLHHPH LAQLHAAYLS PRHLVLILEL CSGPELLPSL AERESYSESD VKDYLWQMLS 8700
ATQYLHAQHI LHLDLRSENM MVTEYNLLKV IDLGNAQSLD QEKVPAPENF KDYLETMAPE 8760
LLEGQGAVPQ TDIWAIGVTA FIMLSGEYPE SSEGTRDLQK GLRKGLIRLS RCYAGLSGGA 8820
VAFLQSSLCA QPWGRPCAST CLQCGWLTEE GPTGSRPTPV TFPTVRLRAF VREREKRRAL 8880
LYKKHNLAQV R 8891 
Gene Ontology
 GO:0031430; C:M band; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR011009; Kinase-like_dom.
 IPR020675; Myosin_light_ch_kinase-rel.
 IPR020682; Obscurin-myosin_light-ch_kin.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR001452; SH3_domain.
 IPR008266; Tyr_kinase_AS. 
Pfam
 PF00041; fn3
 PF07679; I-set
 PF00612; IQ
 PF00069; Pkinase
 PF00621; RhoGEF 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2
 SM00015; IQ
 SM00233; PH
 SM00220; S_TKc
 SM00326; SH3 
PROSITE
 PS00741; DH_1
 PS50010; DH_2
 PS50853; FN3
 PS50835; IG_LIKE
 PS50096; IQ
 PS50003; PH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS00109; PROTEIN_KINASE_TYR
 PS50002; SH3 
PRINTS