UniProt Accession

 RNF24_HUMAN; Q9Y225; D3DVZ2; D3DVZ3; Q9UMH1 

Genbank Protein ID

 AL096778; BT007406; AL031670; CH471133; CH471133; CH471133; CH471133; BC000213; BC039584; AL079313 

Genbank Nucleotide ID

 CAB46627.1; AAP36074.1; CAB43182.1; EAX10467.1; EAX10468.1; EAX10469.1; EAX10471.1; AAH00213.1; AAH39584.1; CAB45279.1 

Protein Name

 RING finger protein 24 

Protein Synonyms/Alias

  

Gene Name

 RNF24 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	HKEFYAYKQVILKEK	ubiquitination	[1, 2]
128	FHRKCLIKWLEVRKV	ubiquitination	[1, 3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May play a role in TRPCs intracellular trafficking. 

Sequence Annotation

 ZN_FING 78 119 RING-type.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Golgi apparatus; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 148 AA 

Protein Sequence

Gene Ontology

 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF13639; zf-RING_2 

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS