UniProt Accession

 BRK1_HUMAN; Q8WUW1; B2R5E2; Q9P082 

Genbank Protein ID

 AY148219; AY148220; AF161418; AK312155; CH471055; BC001067; BC007929; BC019303 

Genbank Nucleotide ID

 AAN60161.1; AAN60162.1; AAF28978.1; BAG35089.1; EAW64061.1; AAH01067.1; AAH07929.1; AAH19303.1 

Protein Name

 Protein BRICK1 

Protein Synonyms/Alias

 BRK1 

Gene Name

 BRK1 

Gene Synonyms/Alias

 C3orf10; HSPC300; MDS027 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	EIITSSIKKIADFLN	ubiquitination	[1]
31	IITSSIKKIADFLNS	ubiquitination	[2, 3]
53	RLATLNEKLTALERR	ubiquitination	[1, 2, 3]
70	YIEARVTKGETLTRT	ubiquitination	[3]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 75 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
 GO:0048870; P:cell motility; IEA:Compara.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS