CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015936
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein phosphatase 1 regulatory subunit 42 
Protein Synonyms/Alias
 Leucine-rich repeat-containing protein 67 
Gene Name
 PPP1R42 
Gene Synonyms/Alias
 LRRC67 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
286VYYPQVGKPKLAFFSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis (By similarity). 
Sequence Annotation
 REPEAT 29 50 LRR 1.
 REPEAT 51 72 LRR 2.
 REPEAT 73 94 LRR 3.
 REPEAT 95 116 LRR 4.
 REPEAT 117 138 LRR 5.
 REPEAT 147 168 LRR 6.
 REPEAT 169 190 LRR 7.
 DOMAIN 204 242 LRRCT.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Leucine-rich repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 355 AA 
Protein Sequence
MVRLTLDLIA RNSNLKPRKE ETISQCLKKI THINFSDKNI DAIEDLSLCK NLSVLYLYDN 60
CISQITNLNY ATNLTHLYLQ NNCISCIENL RSLKKLEKLY LGGNYIAVIE GLEGLGELRE 120
LHVENQRLPL GEKLLFDPRT LHSLAKSLCI LNISNNNIDD ITDLELLENL NQLIAVDNQL 180
LHVKDLEFLL NKLMKLWKID LNGNPVCLKP KYRDRLILVS KSLEFLDGKE IKNIERQFLM 240
NWKASKDAKK ISKKRSSKNE DASNSLISNF KTMHHIVPVY YPQVGKPKLA FFSEIQRYPV 300
NANASPESSE DYTKIIEMGN LSLKQSESLL TKNDVHEPHL FHNPEEKENL FVENE 355 
Gene Ontology
 GO:0005813; C:centrosome; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0002177; C:manchette; ISS:UniProtKB.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0045502; F:dynein binding; ISS:UniProtKB.
 GO:0015631; F:tubulin binding; ISS:UniProtKB.
 GO:0010921; P:regulation of phosphatase activity; IEA:Compara. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4. 
Pfam
 PF12799; LRR_4 
SMART
  
PROSITE
 PS51450; LRR 
PRINTS