CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028349
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial Rho GTPase 
Protein Synonyms/Alias
  
Gene Name
 Rhot1 
Gene Synonyms/Alias
 Rnf135; rCG_34120 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
525EYCARIFKQHFMDSRacetylation[1]
629AMYRALLKQR*****acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Mitochondrial GTPase involved in mitochondrial trafficking (By similarity). 
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; GTP-binding; Hydrolase; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 631 AA 
Protein Sequence
MRAGRVRPLR ASDMKKDVRI LLVGEPRVGK TSLIMSLVSE EFPEEVPPRA EEITIPADVT 60
PERVPTHIVD YSEAEQSDEQ LHQEISQANV ICIVYAVNNK HSIDKVTSRW IPLINERTDK 120
DSRLPLILVG NKSDLVEYSS METILPIMNQ YTEIETCVEC SAKNLKNISE LFYYAQKAVL 180
HPTGPLYCPE EKEMKPACIK ALTRIFKISD QDNDGTLNDA ELNFFQRICF NTPLAPQALE 240
DVKNVVRKHL SDGVADSGLT LRGFLFLHTL FIQRGRHETT WTVLRRFGYD DDLDLTPEYL 300
FPLLKIPPDC TTELNHHAYL FLQSTFDKHD LDRDCALSPD ELKDLFQVFP YIPWGPDVNN 360
TVCTNESGWI TYQGFLSQWT LTTYLDVQRC LEYLGYLGYS ILTEQESQAS AITVTRDKKI 420
DLQKKQTQRN VFRCNVIGVK GCGKTGVLQS LLGRNLMRQK KIRDDHKSYY AINTVYVYGQ 480
EKYLLLHDIS ESEFLTEAEI VCDVVCLVYD VTNPKSFEYC ARIFKQHFMD SRIPCLIVAA 540
KSDLHEVKQE HSVSPTDFCR KHKMPPPQAF TCNTADAPSK DIFVKLTTMA MYPHVTQADL 600
KSSTFWLRAS FGATVFAVVG FAMYRALLKQ R 631 
Gene Ontology
 GO:0031307; C:integral to mitochondrial outer membrane; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0019725; P:cellular homeostasis; IEA:Compara.
 GO:0006184; P:GTP catabolic process; IEA:GOC.
 GO:0047497; P:mitochondrion transport along microtubule; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR013566; EF_hand_assoc_1.
 IPR013567; EF_hand_assoc_2.
 IPR002048; EF_hand_dom.
 IPR020860; MIRO.
 IPR013684; MIRO-like.
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR021181; Small_GTPase_Miro. 
Pfam
 PF08355; EF_assoc_1
 PF08356; EF_assoc_2
 PF13405; EF_hand_4
 PF08477; Miro
 PF00071; Ras 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS51423; MIRO 
PRINTS
 PR00449; RASTRNSFRMNG.