| Tag | Content |
|---|
| CPLM ID | CPLM-013649 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Xaa-Pro dipeptidase |
Protein Synonyms/Alias | X-Pro dipeptidase; Imidodipeptidase; Peptidase D; Proline dipeptidase; Prolidase |
Gene Name | Pepd |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 110 | SYATWMGKIHSKEHF | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because of the high level of iminoacids in collagen (By similarity). |
Sequence Annotation | METAL 276 276 Manganese 1 (By similarity).
METAL 287 287 Manganese 1 (By similarity).
METAL 287 287 Manganese 2 (By similarity).
METAL 370 370 Manganese 2 (By similarity).
METAL 412 412 Manganese 2 (By similarity).
METAL 452 452 Manganese 1 (By similarity).
METAL 452 452 Manganese 2 (By similarity).
MOD_RES 2 2 N-acetylalanine (Potential). |
Keyword | Acetylation; Collagen degradation; Complete proteome; Dipeptidase; Hydrolase; Manganese; Metal-binding; Metalloprotease; Protease; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 492 AA |
Protein Sequence | MASTVRPSFS LGNETLKVPL ALFALNRQRL CERLRKNGAV QAGSAVVLQG GEEMQRYCTD 60
TSIIFRQESF FHWAFGVIES GCYGVIDVDT GKSTLFVPRL PASYATWMGK IHSKEHFKEK 120
YAVDDVQYAD EIASVLTSRN PSVLLTLRGV NTDSGNVCRE ASFEGISKFT VNNTILHPEI 180
VECRVFKTDM ELEVLRYTNR ISSEAHREVM KAVKVGMKEY EMESLFQHYC YSKGGMRHTS 240
YTCICCSGEN AAVLHYGHAG APNDRTIKDG DICLFDMGGE YYCFASDITC SFPANGKFTD 300
DQKAIYEAVL RSCRTVMSTM KPGVWWPDMH RLADRIHLEE LTRIGLLSGS VDAMLQVHLG 360
AVFMPHGLGH FLGLDVHDVG GYPEGVERID EPGLRSLRTA RHLEPGMVLT VEPGIYFIDH 420
LLDQALADPA QACFFNQEVL QRFRNFGGVR IEEDVVVTDS GMELLTCVPR TVEEIEACMA 480
GCDKALAPSG PK 492 |
Gene Ontology | GO:0004177; F:aminopeptidase activity; IEA:InterPro. GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW. GO:0030145; F:manganese ion binding; IEA:InterPro. GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW. GO:0009987; P:cellular process; IEA:InterPro. GO:0030574; P:collagen catabolic process; IEA:UniProtKB-KW. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |