UniProt Accession

 GLO2_MOUSE; Q99KB8; Q3TMR4; Q3UCF6; Q8WUR9 

Genbank Protein ID

 AK147022; AK150557; AK151231; AK152742; AK165777; BC004749; BC019817 

Genbank Nucleotide ID

 BAE27615.1; BAE29657.1; BAE30223.1; BAE31462.1; BAE38377.1; AAH04749.1; AAH19817.1 

Protein Name

 Hydroxyacylglutathione hydrolase, mitochondrial 

Protein Synonyms/Alias

 Glyoxalase II; Glx II 

Gene Name

 Hagh 

Gene Synonyms/Alias

 Glo2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
117	GGNEKLVKLEPGLKV	acetylation	[1]
230	EYTVNNLKFARHVEP	acetylation	[1]
279	PFMRVKEKTVQQHAG	acetylation	[1]
301	MRAIRREKDQFKVPR	acetylation	[1]
305	RREKDQFKVPRD***	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid. 

Sequence Annotation

 REGION 192 194 Substrate (By similarity).
 REGION 222 224 Substrate (By similarity).
 REGION 298 301 Substrate (By similarity).
 METAL 103 103 Zinc 1 (By similarity).
 METAL 105 105 Zinc 1 (By similarity).
 METAL 107 107 Zinc 2 (By similarity).
 METAL 108 108 Zinc 2 (By similarity).
 METAL 159 159 Zinc 1 (By similarity).
 METAL 183 183 Zinc 1 (By similarity).
 METAL 183 183 Zinc 2 (By similarity).
 METAL 222 222 Zinc 2 (By similarity).
 MOD_RES 230 230 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative initiation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Mitochondrion; Reference proteome; Transit peptide; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 309 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004416; F:hydroxyacylglutathione hydrolase activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006750; P:glutathione biosynthetic process; IC:MGI. 

Interpro

 IPR001279; Beta-lactamas-like.
 IPR017782; Hydroxyacylglutathione_Hdrlase. 

Pfam

 PF00753; Lactamase_B 

SMART

 SM00849; Lactamase_B 

PROSITE

  

PRINTS