UniProt Accession

 COX2_HUMAN; P00403; Q37526 

Genbank Protein ID

 V00662; J01415; X15759; M25171; D38112; U12690; U12691; U12692; U12693; U12694; AF004339; AY339402; AY339403; AY339404; AY339405; AY339406; AY339407; AY339408; AY339409; AY339410; AY339411; AY339412; AY339413; AY339414; AY339415; AY339416; AY339417; AY339418; AY339419; AY339420; AY339421; AY339422; AY339423; AY339424; AY339425; AY339426; AY339427; AY339428; AY339429; AY339430; AY339431; AY339432; AY339433; AY339434; AY339435; AY339436; AY339437; AY339438; AY339439; AY339440; AY339441; AY339442; AY339443; AY339444; AY339445; AY339446; AY339447; AY339448; AY339449; AY339450; AY339451; AY339452; AY339453; AY339454; AY339455; AY339456; AY339457; AY339458; AY339459; AY339460; AY339461; AY339462; AY339463; AY339464; AY339465; AY339466; AY339467; AY339468; AY339469; AY339470; AY339471; AY339472; AY339473; AY339474; AY339475; AY339476; AY339477; AY339478; AY339479; AY339480; AY339481; AY339482; AY339483; AY339484; AY339485; AY339486; AY339487; AY339488; AY339489; AY339490; AY339492; AY339493; AY339494; AY339495; AY339496; AY339498; AY339499; AY339500; AY339501; AY339502; AY339503; AY339504; AY339505; AY339506; AY339507; AY339508; AY339509; AY339510; AY339511; AY339512; AY339513; AY339514; AY339515; AY339516; AY339517; AY339518; AY339519; AY339520; AY339521; AY339522; AY339523; AY339524; AY339525; AY339526; AY339527; AY339528; AY339529; AY339530; AY339531; AY339532; AY339533; AY339534; AY339535; AY339536; AY339537; AY339538; AY339539; AY339540; AY339541; AY339543; AY339544; AY339545; AY339546; AY339547; AY339548; AY339549; AY339550; AY339551; AY339552; AY339553; AY339555; AY339556; AY339557; AY339558; AY339559; AY339560; AY339561; AY339562; AY339563; AY339564; AY339565; AY339566; AY339567; AY339568; AY339569; AY339570; AY339571; AY339572; AY339573; AY339574; AY339575; AY339576; AY339577; AY339578; AY339579; AY339580; AY339581; AY339582; AY339583; AY339584; AY339585; AY339586; AY339587; AY339588; AY339589; AY339590; AY339591; AY339592; AY339593; AF346963; AF346964; AF346965; AF346966; AF346967; AF346970; AF346972; AF346973; AF346974; AF346975; AF346976; AF346977; AF346978; AF346979; AF346980; AF346981; AF346982; AF346983; AF346984; AF346985; AF346986; AF346988; AF346989; AF346990; AF346991; AF346993; AF346994; AF346995; AF346998; AF346999; AF347000; AF347001; AF347002; AF347003; AF347004; AF347005; AF347006; AF347007; AF347009; AF347010; AF347011; AF347014; AF347015; AY289051; AY289053; AY289054; AY289056; AY289057; AY289058; AY289059; AY289060; AY289061; AY289062; AY289063; AY289064; AY289065; AY289066; AY289067; AY289068; AY289069; AY289071; AY289072; AY289073; AY289074; AY289075; AY289076; AY289077; AY289078; AY289079; AY289080; AY289081; AY289082; AY289083; AY289084; AY289085; AY289086; AY289087; AY289088; AY289089; AY289090; AY289091; AY289092; AY289093; AY289094; AY289095; AY289096; AY289099; AY289100; AY289102; AY495090; AY495091; AY495092; AY495093; AY495094; AY495095; AY495096; AY495097; AY495098; AY495099; AY495100; AY495101; AY495102; AY495103; AY495104; AY495105; AY495106; AY495107; AY495108; AY495109; AY495110; AY495111; AY495112; AY495113; AY495114; AY495115; AY495116; AY495117; AY495118; AY495119; AY495120; AY495121; AY495122; AY495123; AY495124; AY495125; AY495126; AY495127; AY495128; AY495129; AY495130; AY495131; AY495132; AY495133; AY495134; AY495135; AY495136; AY495137; AY495138; AY495139; AY495140; AY495141; AY495142; AY495143; AY495144; AY495145; AY495146; AY495147; AY495148; AY495149; AY495150; AY495151; AY495152; AY495153; AY495154; AY495155; AY495156; AY495157; AY495158; AY495159; AY495160; AY495161; AY495162; AY495163; AY495164; AY495166; AY495167; AY495168; AY495169; AY495170; AY495172; AY495173; AY495174; AY495175; AY495176; AY495177; AY495178; AY495179; AY495180; AY495181; AY495182; AY495183; AY495184; AY495185; AY495186; AY495187; AY495188; AY495189; AY495190; AY495191; AY495192; AY495193; AY495194; AY495195; AY495196; AY495197; AY495198; AY495199; AY495200; AY495201; AY495202; AY495203; AY495204; AY495205; AY495206; AY495207; AY495208; AY495209; AY495210; AY495211; AY495212; AY495213; AY495214; AY495215; AY495216; AY495217; AY495218; AY495219; AY495220; AY495221; AY495223; AY495224; AY495225; AY495226; AY495227; AY495228; AY495229; AY495230; AY495231; AY495232; AY495233; AY495234; AY495235; AY495236; AY495237; AY495238; AY495239; AY495240; AY495241; AY495242; AY495243; AY495244; AY495245; AY495246; AY495247; AY495248; AY495249; AY495250; AY495251; AY495252; AY495253; AY495254; AY495255; AY495256; AY495257; AY495258; AY495259; AY495260; AY495261; AY495262; AY495263; AY495264; AY495265; AY495266; AY495267; AY495268; AY495269; AY495270; AY495271; AY495272; AY495273; AY495274; AY495275; AY495276; AY495277; AY495278; AY495279; AY495280; AY495281; AY495282; AY495283; AY495284; AY495285; AY495286; AY495287; AY495288; AY495289; AY495290; AY495291; AY495292; AY495293; AY495294; AY495295; AY495296; AY495297; AY495298; AY495299; AY495300; AY495301; AY495302; AY495303; AY495304; AY495305; AY495306; AY495307; AY495308; AY495309; AY495310; AY495311; AY495312; AY495313; AY495314; AY495315; AY495316; AY495317; AY495318; AY495319; AY495320; AY495321; AY495322; AY495323; AY495325; AY495326; AY495327; AY495328; AY495329; AY495330; X55654 

Genbank Nucleotide ID

 CAA24029.1; AAB58946.1; CAA33766.1; AAA31850.1; BAA07293.1; AAA20843.1; AAA20844.1; AAA20845.1; AAA20846.1; AAA20847.1; AAB63450.1; AAP89039.1; AAP89052.1; AAP89065.1; AAP89078.1; AAP89091.1; AAP89104.1; AAP89117.1; AAP89130.1; AAP89143.1; AAP89156.1; AAP89169.1; AAP89182.1; AAP89195.1; AAP89208.1; AAP89221.1; AAP89234.1; AAP89247.1; AAP89260.1; AAP89273.1; AAP89286.1; AAP89299.1; AAP89312.1; AAP89325.1; AAP89338.1; AAP89351.1; AAP89364.1; AAP89377.1; AAP89390.1; AAP89403.1; AAP89416.1; AAP89429.1; AAP89442.1; AAP89455.1; AAP89468.1; AAP89481.1; AAP89494.1; AAP89507.1; AAP89520.1; AAP89533.1; AAP89546.1; AAP89559.1; AAP89572.1; AAP89585.1; AAP89598.1; AAP89611.1; AAP89624.1; AAP89637.1; AAP89650.1; AAP89663.1; AAP89676.1; AAP89689.1; AAP89702.1; AAP89715.1; AAP89728.1; AAP89741.1; AAP89754.1; AAP89767.1; AAP89780.1; AAP89793.1; AAP89806.1; AAP89819.1; AAP89832.1; AAP89845.1; AAP89858.1; AAP89871.1; AAP89884.1; AAP89897.1; AAP89910.1; AAP89923.1; AAP89936.1; AAP89949.1; AAP89962.1; AAP89975.1; AAP89988.1; AAP90001.1; AAP90014.1; AAP90027.1; AAP90040.1; AAP90053.1; AAP90066.1; AAP90079.1; AAP90092.1; AAP90105.1; AAP90118.1; AAP90131.1; AAP90144.1; AAP90157.1; AAP90170.1; AAP90183.1; AAP90209.1; AAP90222.1; AAP90235.1; AAP90248.1; AAP90261.1; AAP90287.1; AAP90300.1; AAP90313.1; AAP90326.1; AAP90339.1; AAP90352.1; AAP90365.1; AAP90378.1; AAP90391.1; AAP90404.1; AAP90417.1; AAP90430.1; AAP90443.1; AAP90456.1; AAP90469.1; AAP90482.1; AAP90495.1; AAP90508.1; AAP90521.1; AAP90534.1; AAP90547.1; AAP90560.1; AAP90573.1; AAP90586.1; AAP90599.1; AAP90612.1; AAP90625.1; AAP90638.1; AAP90651.1; AAP90664.1; AAP90677.1; AAP90690.1; AAP90703.1; AAP90716.1; AAP90729.1; AAP90742.1; AAP90755.1; AAP90768.1; AAP90781.1; AAP90794.1; AAP90807.1; AAP90820.1; AAP90833.1; AAP90846.1; AAP90872.1; AAP90885.1; AAP90898.1; AAP90911.1; AAP90924.1; AAP90937.1; AAP90950.1; AAP90963.1; AAP90976.1; AAP90989.1; AAP91002.1; AAP91028.1; AAP91041.1; AAP91054.1; AAP91067.1; AAP91080.1; AAP91093.1; AAP91106.1; AAP91119.1; AAP91132.1; AAP91145.1; AAP91158.1; AAP91171.1; AAP91184.1; AAP91197.1; AAP91210.1; AAP91223.1; AAP91236.1; AAP91249.1; AAP91262.1; AAP91275.1; AAP91288.1; AAP91301.1; AAP91314.1; AAP91327.1; AAP91340.1; AAP91353.1; AAP91366.1; AAP91379.1; AAP91392.1; AAP91405.1; AAP91418.1; AAP91431.1; AAP91444.1; AAP91457.1; AAP91470.1; AAP91483.1; AAP91496.1; AAP91509.1; AAP91522.1; AAK17210.1; AAK17223.1; AAK17236.1; AAK17249.1; AAK17262.1; AAK17301.1; AAK17327.1; AAK17340.1; AAK17353.1; AAK17366.1; AAK17379.1; AAK17392.1; AAK17405.1; AAK17418.1; AAK17431.1; AAK17444.1; AAK17457.1; AAK17470.1; AAK17483.1; AAK17496.1; AAK17509.1; AAK17535.1; AAK17548.1; AAK17561.1; AAK17574.1; AAK17600.1; AAK17613.1; AAK17626.1; AAK17665.1; AAK17678.1; AAK17691.1; AAK17704.1; AAK17717.1; AAK17730.1; AAK17743.1; AAK17756.1; AAK17769.1; AAK17782.1; AAK17808.1; AAK17821.1; AAK17834.1; AAK17873.1; AAK17886.1; AAP47883.1; AAP47909.1; AAP47922.1; AAP47948.1; AAP47961.1; AAP47974.1; AAP47987.1; AAP48000.1; AAP48013.1; AAP48026.1; AAP48039.1; AAP48052.1; AAP48065.1; AAP48078.1; AAP48091.1; AAP48104.1; AAP48117.1; AAP48143.1; AAP48156.1; AAP48169.1; AAP48182.1; AAP48195.1; AAP48208.1; AAP48221.1; AAP48234.1; AAP48247.1; AAP48260.1; AAP48273.1; AAP48286.1; AAP48299.1; AAP48312.1; AAP48325.1; AAP48338.1; AAP48351.1; AAP48364.1; AAP48377.1; AAP48390.1; AAP48403.1; AAP48416.1; AAP48428.1; AAP48441.1; AAP48454.1; AAP48467.1; AAP48506.1; AAP48519.1; AAP48545.1; AAR92499.1; AAR92512.1; AAR92525.1; AAR92538.1; AAR92551.1; AAR92564.1; AAR92577.1; AAR92590.1; AAR92603.1; AAR92616.1; AAR92629.1; AAR92642.1; AAR92655.1; AAR92668.1; AAR92681.1; AAR92694.1; AAR92707.1; AAR92720.1; AAR92733.1; AAR92746.1; AAR92759.1; AAR92772.1; AAR92785.1; AAR92798.1; AAR92811.1; AAR92824.1; AAR92837.1; AAR92850.1; AAR92863.1; AAR92876.1; AAR92889.1; AAR92902.1; AAR92915.1; AAR92928.1; AAR92941.1; AAR92954.1; AAR92967.1; AAR92980.1; AAR92993.1; AAR93006.1; AAR93019.1; AAR93032.1; AAR93045.1; AAR93058.1; AAR93071.1; AAR93084.1; AAR93097.1; AAR93110.1; AAR93123.1; AAR93136.1; AAR93149.1; AAR93162.1; AAR93175.1; AAR93188.1; AAR93201.1; AAR93214.1; AAR93227.1; AAR93240.1; AAR93253.1; AAR93266.1; AAR93279.1; AAR93292.1; AAR93305.1; AAR93318.1; AAR93331.1; AAR93344.1; AAR93357.1; AAR93370.1; AAR93383.1; AAR93396.1; AAR93409.1; AAR93422.1; AAR93435.1; AAR93448.1; AAR93461.1; AAR93487.1; AAR93500.1; AAR93513.1; AAR93526.1; AAR93539.1; AAR93565.1; AAR93578.1; AAR93591.1; AAR93604.1; AAR93617.1; AAR93630.1; AAR93643.1; AAR93656.1; AAR93669.1; AAR93682.1; AAR93695.1; AAR93708.1; AAR93721.1; AAR93734.1; AAR93747.1; AAR93760.1; AAR93773.1; AAR93786.1; AAR93799.1; AAR93812.1; AAR93825.1; AAR93838.1; AAR93851.1; AAR93864.1; AAR93877.1; AAR93890.1; AAR93903.1; AAR93916.1; AAR93929.1; AAR93942.1; AAR93955.1; AAR93968.1; AAR93981.1; AAR93994.1; AAR94007.1; AAR94020.1; AAR94033.1; AAR94046.1; AAR94059.1; AAR94072.1; AAR94085.1; AAR94098.1; AAR94111.1; AAR94124.1; AAR94137.1; AAR94150.1; AAR94163.1; AAR94176.1; AAR94189.1; AAR94202.1; AAR94228.1; AAR94241.1; AAR94254.1; AAR94267.1; AAR94280.1; AAR94293.1; AAR94306.1; AAR94319.1; AAR94332.1; AAR94345.1; AAR94358.1; AAR94371.1; AAR94384.1; AAR94397.1; AAR94410.1; AAR94423.1; AAR94436.1; AAR94449.1; AAR94462.1; AAR94475.1; AAR94488.1; AAR94501.1; AAR94514.1; AAR94527.1; AAR94540.1; AAR94553.1; AAR94566.1; AAR94579.1; AAR94592.1; AAR94605.1; AAR94618.1; AAR94631.1; AAR94644.1; AAR94657.1; AAR94670.1; AAR94683.1; AAR94696.1; AAR94709.1; AAR94722.1; AAR94735.1; AAR94748.1; AAR94761.1; AAR94774.1; AAR94787.1; AAR94800.1; AAR94813.1; AAR94826.1; AAR94839.1; AAR94852.1; AAR94865.1; AAR94878.1; AAR94891.1; AAR94904.1; AAR94917.1; AAR94930.1; AAR94943.1; AAR94956.1; AAR94969.1; AAR94982.1; AAR94995.1; AAR95008.1; AAR95021.1; AAR95034.1; AAR95047.1; AAR95060.1; AAR95073.1; AAR95086.1; AAR95099.1; AAR95112.1; AAR95125.1; AAR95138.1; AAR95151.1; AAR95164.1; AAR95177.1; AAR95190.1; AAR95203.1; AAR95216.1; AAR95229.1; AAR95242.1; AAR95255.1; AAR95268.1; AAR95281.1; AAR95294.1; AAR95307.1; AAR95320.1; AAR95333.1; AAR95346.1; AAR95359.1; AAR95372.1; AAR95385.1; AAR95398.1; AAR95411.1; AAR95424.1; AAR95437.1; AAR95450.1; AAR95463.1; AAR95476.1; AAR95489.1; AAR95502.1; AAR95515.1; AAR95528.1; AAR95554.1; AAR95567.1; AAR95580.1; AAR95593.1; AAR95606.1; AAR95619.1; CAA39187.1 

Protein Name

 Cytochrome c oxidase subunit 2 

Protein Synonyms/Alias

 Cytochrome c oxidase polypeptide II 

Gene Name

 MT-CO2 

Gene Synonyms/Alias

 COII; COXII; MTCO2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
171	AVPTLGLKTDAIPGR	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. 

Sequence Annotation

 METAL 161 161 Copper A (Probable).
 METAL 196 196 Copper A (Probable).
 METAL 200 200 Copper A (Probable).
 METAL 204 204 Copper A (Probable).  

Keyword

 3D-structure; Complete proteome; Copper; Disease mutation; Electron transport; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0004129; F:cytochrome-c oxidase activity; NAS:UniProtKB.
 GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; NAS:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR001505; Copper_CuA.
 IPR008972; Cupredoxin.
 IPR014222; Cyt_c_oxidase_su2.
 IPR002429; Cyt_c_oxidase_su2_C.
 IPR011759; Cyt_c_oxidase_su2_TM_dom. 

Pfam

 PF00116; COX2
 PF02790; COX2_TM 

SMART

  

PROSITE

 PS00078; COX2
 PS50857; COX2_CUA
 PS50999; COX2_TM 

PRINTS