UniProt Accession

 KAD4_HUMAN; P27144; B2R927; D3DQ62; Q6IBH4; Q6NXQ5; Q8IUU9 

Genbank Protein ID

 X60673; CR456830; AK313611; AL356212; AC099680; CH471059; CH471059; CH471059; BC016180; BC040224; BC066944; BC136886; BC136887; BC148270; BC146653 

Genbank Nucleotide ID

 CAA43088.1; CAG33111.1; BAG36374.1; CAI22412.1; CAI22412.1; EAX06538.1; EAX06540.1; EAX06544.1; AAH16180.1; AAH40224.1; AAH66944.1; AAI36887.1; AAI36888.1; AAI48271.1; AAI46654.1 

Protein Name

 GTP:AMP phosphotransferase AK4, mitochondrial 

Protein Synonyms/Alias

 Adenylate kinase 3-like; Adenylate kinase isoenzyme 4; AK 4 

Gene Name

 AK4 

Gene Synonyms/Alias

 AK3; AK3L1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
179	RQYKDVAKPVIELYK	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. 

Sequence Annotation

 NP_BIND 15 20 NTP.
 NP_BIND 62 64 AMP.
 NP_BIND 89 92 AMP.
 NP_BIND 135 136 NTP (By similarity).
 REGION 35 64 NMPbind.
 REGION 125 162 LID.
 BINDING 36 36 AMP.
 BINDING 41 41 AMP (By similarity).
 BINDING 96 96 AMP (By similarity).
 BINDING 126 126 NTP.
 BINDING 170 170 AMP.
 BINDING 199 199 NTP; via carbonyl oxygen.  

Keyword

 3D-structure; ATP-binding; Complete proteome; GTP-binding; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 223 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; ISS:BHF-UCL.
 GO:0004017; F:adenylate kinase activity; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0046899; F:nucleoside triphosphate adenylate kinase activity; IDA:BHF-UCL.
 GO:0046033; P:AMP metabolic process; IDA:BHF-UCL.
 GO:0046034; P:ATP metabolic process; IDA:BHF-UCL.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0018885; P:carbon tetrachloride metabolic process; IEA:Compara.
 GO:0046039; P:GTP metabolic process; IDA:BHF-UCL.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043643; P:tetracycline metabolic process; IEA:Compara. 

Interpro

 IPR006259; Adenyl_kin_sub.
 IPR000850; Adenylate_kin.
 IPR007862; Adenylate_kinase_lid-dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK
 PF05191; ADK_lid 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.