CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026385
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pleckstrin homology domain-containing family M member 2 
Protein Synonyms/Alias
  
Gene Name
 PLEKHM2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MEPGEVKDRILENIubiquitination[1]
20NISLSVKKLQSYFAAubiquitination[1]
707MEKLALAKFVAQESKubiquitination[1]
714KFVAQESKCEASAVTubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 999 AA 
Protein Sequence
MEPGEVKDRI LENISLSVKK LQSYFAACED EIPAIRNHDK VLQRLCEHLD HALLYGLQDL 60
SSGYWVLVVH FTRREAIKQI EVLQHVATNL GRSRAWLYLA LNENSLESYL RLFQENLGLL 120
HKYYVKNALV CSHDHLTLFL TLVSGLEFIR FELDLDAPYL DLAPYMPDYY KPQYLLDFED 180
RLPSSVHGSD SLSLNSFNSV TSTNLEWDDS AIAPSSEDGD LTDTVSGPRS TASDLTSSKA 240
STRSPTQRQN PFNEEPAETV SSSDTTPVHT TSQEKEEAQA LDPPDACTEL EVIRVTKKKK 300
IGKKKKSRSD EEASPLHPAC SQKKCAKQGD GDSRNGSPSL GRDSPDTMLA SPQEEGEGPS 360
STTESSERSE PGLLIPEMKD TSMERLGQPL SKVIDQLNGQ LDPSTWCSRA EPPDQSFRTG 420
SPGDAPERPP LCDFSEGLSA PMDFYRFTVE SPSTVTSGGG HHDPAGLGQP LHVPSSPEAA 480
GQEEEGGGGE GQTPRPLEDT TREAQELEAQ LSLVREGPVS EPEPGTQEVL CQLKRDQPSP 540
CLSSAEDSGV DEGQGSPSEM VHSSEFRVDN NHLLLLMIHV FRENEEQLFK MIRMSTGHME 600
GNLQLLYVLL TDCYVYLLRK GATEKPYLVE EAVSYNELDY VSVGLDQQTV KLVCTNRRKQ 660
FLLDTADVAL AEFFLASLKS AMIKGCREPP YPSILTDATM EKLALAKFVA QESKCEASAV 720
TVRFYGLVHW EDPTDESLGP TPCHCSPPEG TITKEGMLHY KAGTSYLGKE HWKTCFVVLS 780
NGILYQYPDR TDVIPLLSVN MGGEQCGGCR RANTTDRPHA FQVILSDRPC LELSAESEAE 840
MAEWMQHLCQ AVSKGVIPQG VAPSPCIPCC LVLTDDRLFT CHEDCQTSFF RSLGTAKLGD 900
ISAVSTEPGK EYCVLEFSQD SQQLLPPWVI YLSCTSELDR LLSALNSGWK TIYQVDLPHT 960
AIQEASNKKK FEDALSLIHS AWQRSDSLCR GRASRDPWC 999 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR004012; Run. 
Pfam
 PF00169; PH
 PF02759; RUN 
SMART
 SM00233; PH
 SM00593; RUN 
PROSITE
 PS50003; PH_DOMAIN
 PS50826; RUN 
PRINTS