CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011996
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Intraflagellar transport protein 88 homolog 
Protein Synonyms/Alias
 Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10 
Gene Name
 IFT88 
Gene Synonyms/Alias
 TG737; TTC10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
114VRAAGFTKAALRGSAubiquitination[1]
236YQVIVKNKMFSNAGIubiquitination[1]
254NMGNIYLKQRNYSKAubiquitination[1]
263RNYSKAIKFYRMALDubiquitination[1]
277DQVPSVNKQMRIKIMubiquitination[1]
351PLEIDEDKYISPSDDubiquitination[1]
369NLVTEAIKNDHLRQMubiquitination[1]
386ERKAMAEKYIMTSAKubiquitination[1]
430ANDLEINKAVTYLRQubiquitination[1]
438AVTYLRQKDYNQAVEubiquitination[1]
448NQAVEILKVLEKKDSubiquitination[1]
458EKKDSRVKSAAATNLubiquitination[1]
499NPAALTNKGNTVFANubiquitination[1, 2]
511FANGDYEKAAEFYKEubiquitination[1, 2]
517EKAAEFYKEALRNDSubiquitination[1, 2]
681RRSGNYQKALDTYKDubiquitination[1]
687QKALDTYKDTHRKFPubiquitination[1]
713LCTDLGLKDAQEYARubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in primary cilium biogenesis (By similarity). 
Sequence Annotation
 REPEAT 206 239 TPR 1.
 REPEAT 242 275 TPR 2.
 REPEAT 281 314 TPR 3.
 REPEAT 316 347 TPR 4.
 REPEAT 424 457 TPR 5.
 REPEAT 459 492 TPR 6.
 REPEAT 493 526 TPR 7.
 REPEAT 527 560 TPR 8.
 REPEAT 561 594 TPR 9.
 REPEAT 595 628 TPR 10.
 REPEAT 629 662 TPR 11.
 REPEAT 663 696 TPR 12.  
Keyword
 Alternative splicing; Cell projection; Cilium; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 833 AA 
Protein Sequence
MKFTNTKVQM MQNVHLAPET DEDDLYSGYN DYNPIYDIEE LENDAAFQQA VRTSHGRRPP 60
ITAKISSTAV TRPIATGYGS KTSLASSIGR PMTGAIQDGV TRPMTAVRAA GFTKAALRGS 120
AFDPLSQSRG PASPLEAKKK DSPEEKIKQL EKEVNELVEE SCIANSCGDL KLALEKAKDA 180
GRKERVLVRQ REQVTTPENI NLDLTYSVLF NLASQYSVNE MYAEALNTYQ VIVKNKMFSN 240
AGILKMNMGN IYLKQRNYSK AIKFYRMALD QVPSVNKQMR IKIMQNIGVT FIQAGQYSDA 300
INSYEHIMSM APNLKAGYNL TICYFAIGDR EKMKKAFQKL ITVPLEIDED KYISPSDDPH 360
TNLVTEAIKN DHLRQMERER KAMAEKYIMT SAKLIAPVIE TSFAAGYDWC VEVVKASQYV 420
ELANDLEINK AVTYLRQKDY NQAVEILKVL EKKDSRVKSA AATNLSALYY MGKDFAQASS 480
YADIAVNSDR YNPAALTNKG NTVFANGDYE KAAEFYKEAL RNDSSCTEAL YNIGLTYEKL 540
NRLDEALDCF LKLHAILRNS AEVLYQIANI YELMENPSQA IEWLMQVVSV IPTDPQVLSK 600
LGELYDREGD KSQAFQYYYE SYRYFPCNIE VIEWLGAYYI DTQFWEKAIQ YFERASLIQP 660
TQVKWQLMVA SCFRRSGNYQ KALDTYKDTH RKFPENVECL RFLVRLCTDL GLKDAQEYAR 720
KLKRLEKMKE IREQRIKSGR DGSGGSRGKR EGSASGDSGQ NYSASSKGER LSARLRALPG 780
TNEPYESSSN KEIDASYVDP LGPQIERPKT AAKKRIDEDD FADEELGDDL LPE 833 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0005814; C:centriole; ISS:UniProtKB.
 GO:0035085; C:cilium axoneme; IEA:Compara.
 GO:0030992; C:intraflagellar transport particle B; ISS:BHF-UCL.
 GO:0005932; C:microtubule basal body; ISS:UniProtKB.
 GO:0031514; C:motile cilium; ISS:BHF-UCL.
 GO:0031512; C:motile primary cilium; IEA:Compara.
 GO:0032391; C:photoreceptor connecting cilium; IEA:Compara.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0060411; P:cardiac septum morphogenesis; IEA:Compara.
 GO:0060271; P:cilium morphogenesis; ISS:UniProtKB.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0009953; P:dorsal/ventral pattern formation; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0048568; P:embryonic organ development; IEA:Compara.
 GO:0003382; P:epithelial cell morphogenesis; IEA:Compara.
 GO:0048853; P:forebrain morphogenesis; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0060426; P:lung vasculature development; IEA:Compara.
 GO:0045862; P:positive regulation of proteolysis; IEA:Compara.
 GO:0016485; P:protein processing; IEA:Compara.
 GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0007224; P:smoothened signaling pathway; IEA:Compara.
 GO:0021537; P:telencephalon development; IEA:Compara. 
Interpro
 IPR006597; Sel1-like.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1
 PF07719; TPR_2
 PF13174; TPR_6
 PF13181; TPR_8 
SMART
 SM00671; SEL1
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS