UniProt Accession

 GFAP_MOUSE; P03995; A1E2H7; A2AH87; B2RTI7; Q09J71; Q3USS4; Q496R4; Q496S3; Q7TQ30; Q80VX6; Q925K2; Q925K3 

Genbank Protein ID

 X02801; AK140151; AL731670; AY279974; X78141; BC100728; BC100737; BC101968; BC103571; BC139357; BC139358; K01347; M25937; AF332061; AF332062; EF101554; DQ887822; AY142200 

Genbank Nucleotide ID

 CAA26571.1; BAE24257.1; CAM25115.1; AAP33501.1; CAA55020.1; AAI00729.1; AAI00738.1; AAI01969.1; AAI03572.1; AAI39358.1; AAI39359.1; AAA37678.1; AAA37679.1; AAK56090.1; AAK56091.1; ABK96803.1; ABI54133.1; AAN87913.1 

Protein Name

 Glial fibrillary acidic protein 

Protein Synonyms/Alias

 GFAP 

Gene Name

 Gfap 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
83	RFASYIEKVRFLEQQ	ubiquitination	[1]
92	RFLEQQNKALAAELN	ubiquitination	[1]
108	LRAKEPTKLADVYQA	ubiquitination	[1]
186	ARVDLERKVESLEEE	ubiquitination	[1]
199	EEIQFLRKIYEEEVR	ubiquitination	[1]
257	TEEWYRSKFADLTDA	ubiquitination	[1]
336	EEEGQSLKEEMARHL	ubiquitination	[1]
394	RETSLDTKSVSEGHL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. 

Sequence Annotation

 REGION 1 69 Head.
 REGION 70 374 Rod.
 REGION 70 101 Coil 1A.
 REGION 102 112 Linker 1.
 REGION 113 211 Coil 1B.
 REGION 212 227 Linker 12.
 REGION 228 249 Coil 2A.
 REGION 250 253 Linker 2.
 REGION 254 374 Coil 2B.
 REGION 375 430 Tail.
 MOD_RES 7 7 Phosphothreonine; by AURKB and ROCK1 (By
 MOD_RES 12 12 Phosphoserine; by AURKB and ROCK1 (By
 MOD_RES 35 35 Phosphoserine; by AURKB and ROCK1 (By
 MOD_RES 40 40 Phosphothreonine.
 MOD_RES 107 107 Phosphothreonine (By similarity).
 MOD_RES 380 380 Phosphothreonine (By similarity).  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Intermediate filament; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 430 AA 

Protein Sequence

Gene Ontology

 GO:0097449; C:astrocyte projection; IDA:MGI.
 GO:0044297; C:cell body; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005882; C:intermediate filament; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; IEA:Compara.
 GO:0005198; F:structural molecule activity; IMP:MGI.
 GO:0014002; P:astrocyte development; IGI:MGI.
 GO:0060020; P:Bergmann glial cell differentiation; IMP:MGI.
 GO:0030198; P:extracellular matrix organization; IMP:MGI.
 GO:0045109; P:intermediate filament organization; IMP:MGI.
 GO:0060291; P:long-term synaptic potentiation; IMP:MGI.
 GO:0010977; P:negative regulation of neuron projection development; IMP:MGI.
 GO:0031102; P:neuron projection regeneration; IMP:MGI.
 GO:0010625; P:positive regulation of Schwann cell proliferation; IMP:MGI.
 GO:0051580; P:regulation of neurotransmitter uptake; IMP:MGI.
 GO:0009611; P:response to wounding; IEA:Compara. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR006821; Intermed_filament_DNA-bd.
 IPR018039; Intermediate_filament_CS. 

Pfam

 PF00038; Filament
 PF04732; Filament_head 

SMART

  

PROSITE

 PS00226; IF 

PRINTS