| Tag | Content |
|---|
| CPLM ID | CPLM-022640 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier organic anion transporter family member 1A1 |
Protein Synonyms/Alias | Sodium-independent organic anion-transporting polypeptide 1; OATP-1; Solute carrier family 21 member 1 |
Gene Name | Slco1a1 |
Gene Synonyms/Alias | Oatp1a1; Slc21a1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 643 | DTELAEMKLTEKESE | ubiquitination | [1] | | 647 | AEMKLTEKESECTDV | ubiquitination | [1] | | 659 | TDVCRSPKVENDGEL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates the Na(+)-independent transport of organic anions such as taurocholate, prostaglandin E2 (PGE2), dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate, sulfobromophthalein (BSP), ouabain and gadoxetate. |
Sequence Annotation | DOMAIN 433 488 Kazal-like.
MOD_RES 634 634 Phosphoserine (By similarity).
CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).
CARBOHYD 135 135 N-linked (GlcNAc...) (Potential).
CARBOHYD 483 483 N-linked (GlcNAc...) (Potential).
CARBOHYD 492 492 N-linked (GlcNAc...) (Potential).
DISULFID 439 465 By similarity.
DISULFID 443 454 By similarity.
DISULFID 445 469 By similarity. |
Keyword | Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 670 AA |
Protein Sequence | MEETEKKVAT QEGRFFSKMK VFLMSLTCAY LAKSLSGVYM NSMLTQIERQ FGIPTSVVGF 60
ITGSFEIGNL LLIVFVSYFG RKLHRPIIIG VGCVVMGLGC FLMASPHFLM GRYKYETTIS 120
PTSNLSSNSF LCIENRTQTL KPTQDPTECV KEIKSLMWIY VLIGNTMRGI GETPIMPLGI 180
SYIEDFAKSE NSPLYIGILE MGKIVGPIIG LLLGSFFARV YVDIGSVNTD DLTITPTDTR 240
WVGAWWIGFL VCAGVNILTS IPFFFFPKTL PKKELQDNVD VTKYEKVEKH RERAKKENLG 300
ITKDFLPFMK SLCCNPIYML FSLTSVLQIN GFASTFTFLP KYLEQQYGKS TSEAVFLIGV 360
YSLPPVCLGY LISGFIMKKF KITVKKAAYI AFGLSLSEYF IFLCNYLLTC DNFPVAGLTT 420
SYKGVQHPLY GEKNVLADCN TRCSCLTDTW DPVCGDNGLA YMSACLAGCE KSVGTGTNMV 480
FQNCSCIGSS GNSSAVLGLC KKGPECDNKL QYFLIKSVFS SFIFSLAAIP GYMVLLRCVK 540
SEEKSIGVGL HAFFIRLLAG IPAPVYFGAL IDRTCLHWGT LKCGQPGACR MYDINRFRHI 600
YLGLPAAVRG SSFLPAVFIL ILMRKFHFPG DIHSPDTELA EMKLTEKESE CTDVCRSPKV 660
ENDGELKTKL 670 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IDA:MGI. GO:0031526; C:brush border membrane; IEA:Compara. GO:0005887; C:integral to plasma membrane; IDA:MGI. GO:0015125; F:bile acid transmembrane transporter activity; IEA:Compara. GO:0008514; F:organic anion transmembrane transporter activity; IDA:MGI. GO:0015349; F:thyroid hormone transmembrane transporter activity; IEA:Compara. GO:0050892; P:intestinal absorption; IEA:Compara. GO:0031100; P:organ regeneration; IEA:Compara. GO:0035634; P:response to stilbenoid; IEP:UniProtKB. GO:0033574; P:response to testosterone stimulus; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |